FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1903696312> ?p ?o ?g. }

• W1903696312 endingPage "e0130398" @default.
• W1903696312 startingPage "e0130398" @default.
• W1903696312 abstract "This study underlines the importance of cinnamon, a commonly used natural spice and flavoring material, and its metabolite sodium benzoate (NaB) in attenuating oxidative stress and protecting memory and learning in an animal model of Alzheimer’s disease (AD). NaB, but not sodium formate, was found to inhibit LPS-induced production of reactive oxygen species (ROS) in mouse microglial cells. Similarly, NaB also inhibited fibrillar amyloid beta (Aβ)- and 1-methyl-4-phenylpyridinium(+)-induced microglial production of ROS. Although NaB reduced the level of cholesterol in vivo in mice, reversal of the inhibitory effect of NaB on ROS production by mevalonate, and geranylgeranyl pyrophosphate, but not cholesterol, suggests that depletion of intermediates, but not end products, of the mevalonate pathway is involved in the antioxidant effect of NaB. Furthermore, we demonstrate that an inhibitor of p21rac geranylgeranyl protein transferase suppressed the production of ROS and that NaB suppressed the activation of p21rac in microglia. As expected, marked activation of p21rac was observed in the hippocampus of subjects with AD and 5XFAD transgenic (Tg) mouse model of AD. However, oral feeding of cinnamon (Cinnamonum verum) powder and NaB suppressed the activation of p21rac and attenuated oxidative stress in the hippocampus of Tg mice as evident by decreased dihydroethidium (DHE) and nitrotyrosine staining, reduced homocysteine level and increased level of reduced glutathione. This was accompanied by suppression of neuronal apoptosis, inhibition of glial activation, and reduction of Aβ burden in the hippocampus and protection of memory and learning in transgenic mice. Therefore, cinnamon powder may be a promising natural supplement in halting or delaying the progression of AD." @default.
• W1903696312 created "2016-06-24" @default.
• W1903696312 creator A5034797279 @default.
• W1903696312 creator A5043424252 @default.
• W1903696312 creator A5071763108 @default.
• W1903696312 creator A5083951715 @default.
• W1903696312 creator A5087133073 @default.
• W1903696312 date "2015-06-23" @default.
• W1903696312 modified "2023-10-15" @default.
• W1903696312 title "Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease" @default.
• W1903696312 cites W1175152041 @default.
• W1903696312 cites W1533236567 @default.
• W1903696312 cites W1662308449 @default.
• W1903696312 cites W1740492231 @default.
• W1903696312 cites W1878700164 @default.
• W1903696312 cites W1889306845 @default.
• W1903696312 cites W1896970469 @default.
• W1903696312 cites W1942274382 @default.
• W1903696312 cites W1960543132 @default.
• W1903696312 cites W1965342510 @default.
• W1903696312 cites W1969999276 @default.
• W1903696312 cites W1975579571 @default.
• W1903696312 cites W1981034601 @default.
• W1903696312 cites W1983237282 @default.
• W1903696312 cites W1986517451 @default.
• W1903696312 cites W1987469323 @default.
• W1903696312 cites W1987933993 @default.
• W1903696312 cites W1993213120 @default.
• W1903696312 cites W2001173104 @default.
• W1903696312 cites W2006717582 @default.
• W1903696312 cites W2009827892 @default.
• W1903696312 cites W2015032490 @default.
• W1903696312 cites W2018546081 @default.
• W1903696312 cites W2018954820 @default.
• W1903696312 cites W2024702932 @default.
• W1903696312 cites W2026362697 @default.
• W1903696312 cites W2039069312 @default.
• W1903696312 cites W2042964886 @default.
• W1903696312 cites W2049262684 @default.
• W1903696312 cites W2079004695 @default.
• W1903696312 cites W2080477006 @default.
• W1903696312 cites W2080984707 @default.
• W1903696312 cites W2081096957 @default.
• W1903696312 cites W2090150679 @default.
• W1903696312 cites W2099146087 @default.
• W1903696312 cites W2106910268 @default.
• W1903696312 cites W2124634545 @default.
• W1903696312 cites W2131451331 @default.
• W1903696312 cites W2156386840 @default.
• W1903696312 cites W2167886264 @default.
• W1903696312 cites W4238331970 @default.
• W1903696312 cites W4247759744 @default.
• W1903696312 cites W83226879 @default.
• W1903696312 doi "https://doi.org/10.1371/journal.pone.0130398" @default.
• W1903696312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4478015" @default.
• W1903696312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26102198" @default.
• W1903696312 hasPublicationYear "2015" @default.
• W1903696312 type Work @default.
• W1903696312 sameAs 1903696312 @default.
• W1903696312 citedByCount "75" @default.
• W1903696312 countsByYear W19036963122015 @default.
• W1903696312 countsByYear W19036963122016 @default.
• W1903696312 countsByYear W19036963122017 @default.
• W1903696312 countsByYear W19036963122018 @default.
• W1903696312 countsByYear W19036963122019 @default.
• W1903696312 countsByYear W19036963122020 @default.
• W1903696312 countsByYear W19036963122021 @default.
• W1903696312 countsByYear W19036963122022 @default.
• W1903696312 countsByYear W19036963122023 @default.
• W1903696312 crossrefType "journal-article" @default.
• W1903696312 hasAuthorship W1903696312A5034797279 @default.
• W1903696312 hasAuthorship W1903696312A5043424252 @default.
• W1903696312 hasAuthorship W1903696312A5071763108 @default.
• W1903696312 hasAuthorship W1903696312A5083951715 @default.
• W1903696312 hasAuthorship W1903696312A5087133073 @default.
• W1903696312 hasBestOaLocation W19036963121 @default.
• W1903696312 hasConcept C126322002 @default.
• W1903696312 hasConcept C134018914 @default.
• W1903696312 hasConcept C181199279 @default.
• W1903696312 hasConcept C185592680 @default.
• W1903696312 hasConcept C2776151105 @default.
• W1903696312 hasConcept C2776914184 @default.
• W1903696312 hasConcept C2777622882 @default.
• W1903696312 hasConcept C2778004101 @default.
• W1903696312 hasConcept C2779385521 @default.
• W1903696312 hasConcept C2779719074 @default.
• W1903696312 hasConcept C2779830541 @default.
• W1903696312 hasConcept C48349386 @default.
• W1903696312 hasConcept C538909803 @default.
• W1903696312 hasConcept C55493867 @default.
• W1903696312 hasConcept C71924100 @default.
• W1903696312 hasConcept C86803240 @default.
• W1903696312 hasConcept C98274493 @default.
• W1903696312 hasConceptScore W1903696312C126322002 @default.
• W1903696312 hasConceptScore W1903696312C134018914 @default.
• W1903696312 hasConceptScore W1903696312C181199279 @default.
• W1903696312 hasConceptScore W1903696312C185592680 @default.
• W1903696312 hasConceptScore W1903696312C2776151105 @default.

• next