FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1904014781> ?p ?o ?g. }

• W1904014781 endingPage "44" @default.
• W1904014781 startingPage "37" @default.
• W1904014781 abstract "Purpose: The aim of the present study was to investigate the safety and potential efficacy of subconjunctival interferon-α2b (IFN-α), either alone or in combination with 5-fluorouracil (5-FU), in reducing the risk of failure of glaucoma surgery. Methods: A prospective, masked randomized phase II study was undertaken in which patients received three subconjunctival injections per week for 3–4 weeks postoperatively. Three treatments were compared: (i) IFN-α (1 × 106 IU per dose); (ii) 5-FU (5 mg per dose); and (iii) alternating IFN-α and 5-FU (BOTH). The primary outcome measures were: (i) rate of successful control of intra-ocular pressure without further surgery; and (ii) the incidence of side effects. Results: Fifty-seven patients undergoing glaucoma surgery with an increased risk of failure were evaluated, including 23 patients (40%) undergoing trabeculectomy combined with extracapsular cataract extraction as well as other conventional high-risk groups. With 53 patients (93%) completing 2 years follow up, there was no significant difference in success rates among the three groups. Intra-ocular pressure was controlled without further surgery in 79% of patients (95% confidence interval (CI): 61, 97%) receiving IFN-α, in 89% of patients (76, 100%) receiving 5-FU and in 89% of patients (76, 100%) receiving BOTH. Side effects were similar among the three groups. Conclusions: These results are consistent with a beneficial effect of IFN-α2b given either alone or in combination with 5-FU after glaucoma filtering surgery. However, the lack of a clear and substantial benefit over conventional anti-fibrotic therapy does not support the further clinical evaluation of these treatments." @default.
• W1904014781 created "2016-06-24" @default.
• W1904014781 creator A5001215128 @default.
• W1904014781 creator A5010807977 @default.
• W1904014781 creator A5012233692 @default.
• W1904014781 creator A5034006045 @default.
• W1904014781 creator A5037125817 @default.
• W1904014781 creator A5060316399 @default.
• W1904014781 date "1999-02-01" @default.
• W1904014781 modified "2023-10-04" @default.
• W1904014781 title "A randomized phase II trial of interferon-α2b versus 5-fluorouracil after trabeculectomy*" @default.
• W1904014781 cites W1964292610 @default.
• W1904014781 cites W1970700905 @default.
• W1904014781 cites W1971250522 @default.
• W1904014781 cites W1975618693 @default.
• W1904014781 cites W1977149291 @default.
• W1904014781 cites W1980388249 @default.
• W1904014781 cites W1998424597 @default.
• W1904014781 cites W2000035475 @default.
• W1904014781 cites W2017011686 @default.
• W1904014781 cites W2027852751 @default.
• W1904014781 cites W2027937272 @default.
• W1904014781 cites W2037537056 @default.
• W1904014781 cites W2039840402 @default.
• W1904014781 cites W2047377654 @default.
• W1904014781 cites W2051126611 @default.
• W1904014781 cites W2053506958 @default.
• W1904014781 cites W2057275950 @default.
• W1904014781 cites W2065498040 @default.
• W1904014781 cites W2091728997 @default.
• W1904014781 cites W2093042258 @default.
• W1904014781 cites W2094388405 @default.
• W1904014781 cites W2097291411 @default.
• W1904014781 cites W2101531767 @default.
• W1904014781 cites W2125879715 @default.
• W1904014781 cites W2141779237 @default.
• W1904014781 cites W2151560019 @default.
• W1904014781 cites W2162342682 @default.
• W1904014781 cites W2163334299 @default.
• W1904014781 cites W2284629536 @default.
• W1904014781 cites W2335838053 @default.
• W1904014781 cites W2409781565 @default.
• W1904014781 cites W3142292247 @default.
• W1904014781 cites W67481179 @default.
• W1904014781 cites W2016846489 @default.
• W1904014781 doi "https://doi.org/10.1046/j.1440-1606.1999.00165.x" @default.
• W1904014781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10080336" @default.
• W1904014781 hasPublicationYear "1999" @default.
• W1904014781 type Work @default.
• W1904014781 sameAs 1904014781 @default.
• W1904014781 citedByCount "23" @default.
• W1904014781 countsByYear W19040147812013 @default.
• W1904014781 countsByYear W19040147812015 @default.
• W1904014781 countsByYear W19040147812017 @default.
• W1904014781 crossrefType "journal-article" @default.
• W1904014781 hasAuthorship W1904014781A5001215128 @default.
• W1904014781 hasAuthorship W1904014781A5010807977 @default.
• W1904014781 hasAuthorship W1904014781A5012233692 @default.
• W1904014781 hasAuthorship W1904014781A5034006045 @default.
• W1904014781 hasAuthorship W1904014781A5037125817 @default.
• W1904014781 hasAuthorship W1904014781A5060316399 @default.
• W1904014781 hasConcept C118487528 @default.
• W1904014781 hasConcept C120665830 @default.
• W1904014781 hasConcept C121332964 @default.
• W1904014781 hasConcept C126322002 @default.
• W1904014781 hasConcept C141071460 @default.
• W1904014781 hasConcept C168563851 @default.
• W1904014781 hasConcept C188816634 @default.
• W1904014781 hasConcept C2776694085 @default.
• W1904014781 hasConcept C2776766258 @default.
• W1904014781 hasConcept C2777824320 @default.
• W1904014781 hasConcept C2778527774 @default.
• W1904014781 hasConcept C2780456651 @default.
• W1904014781 hasConcept C2781092963 @default.
• W1904014781 hasConcept C44249647 @default.
• W1904014781 hasConcept C61511704 @default.
• W1904014781 hasConcept C71924100 @default.
• W1904014781 hasConceptScore W1904014781C118487528 @default.
• W1904014781 hasConceptScore W1904014781C120665830 @default.
• W1904014781 hasConceptScore W1904014781C121332964 @default.
• W1904014781 hasConceptScore W1904014781C126322002 @default.
• W1904014781 hasConceptScore W1904014781C141071460 @default.
• W1904014781 hasConceptScore W1904014781C168563851 @default.
• W1904014781 hasConceptScore W1904014781C188816634 @default.
• W1904014781 hasConceptScore W1904014781C2776694085 @default.
• W1904014781 hasConceptScore W1904014781C2776766258 @default.
• W1904014781 hasConceptScore W1904014781C2777824320 @default.
• W1904014781 hasConceptScore W1904014781C2778527774 @default.
• W1904014781 hasConceptScore W1904014781C2780456651 @default.
• W1904014781 hasConceptScore W1904014781C2781092963 @default.
• W1904014781 hasConceptScore W1904014781C44249647 @default.
• W1904014781 hasConceptScore W1904014781C61511704 @default.
• W1904014781 hasConceptScore W1904014781C71924100 @default.
• W1904014781 hasIssue "1" @default.
• W1904014781 hasLocation W19040147811 @default.
• W1904014781 hasLocation W19040147812 @default.
• W1904014781 hasOpenAccess W1904014781 @default.
• W1904014781 hasPrimaryLocation W19040147811 @default.

• next