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- W1904096699 abstract "A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusing on its relation to endothelial dysfunction and cholesterol levels. We discussed sEng as a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. We also addressed a potential interaction of sEng with TGF-β/eNOS or BMP-9 signaling. We suggest soluble endoglin levels to be monitored, because they reflect the progression/treatment efficacy of cardiovascular diseases related to endothelial dysfunction and hypercholesterolemia. A possible role of soluble endoglin as an inducer of endothelial dysfunction however remains to be elucidated." @default.
- W1904096699 created "2016-06-24" @default.
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- W1904096699 date "2015-12-01" @default.
- W1904096699 modified "2023-10-16" @default.
- W1904096699 title "Soluble endoglin, hypercholesterolemia and endothelial dysfunction" @default.
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- W1904096699 doi "https://doi.org/10.1016/j.atherosclerosis.2015.10.003" @default.
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