FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W190461402> ?p ?o ?g. }

• W190461402 abstract "We explored the ability of sodium nitroprusside to modify adhesive and cohesive function of platelets in flowing blood, under normoxic and hypoxic conditions. Aliquots of both untreated and sodium nitroprusside-treated blood were prepared for studies of: (1) platelet aggregation in plasma; (2) erythrocyte deformability; (3) platelet interaction with damaged subendothelium, by using a well-defined perfusion system; and (4) blood gasometry in the perfused samples. Results showed that sodium nitroprusside-treated blood always showed a totally inhibited arachidonic acid-induced platelet aggregation in plasma, as well as significantly increased erythrocyte deformability (0.44+/-0.09 up to 0.66+/-0.05; p<0.05). However, treatment with sodium nitroprusside did not modify the pattern of platelet interaction with subendothelium (percentage of contact, adhesion, thrombus, and covered surface) with respect to untreated blood, under any of the shear rates used (300, 800, and 1800 seconds(-1)), although it significantly reduced the height of thrombi (9.8+/-0.4 vs. 8.3+/-0.4 microm; p<0.05). Hypoxic conditions did not have a noticeable effect in modifying antiplatelet effects of sodium nitroprusside. Additionally, the presence of sodium nitroprusside impaired the normal oxygenation of the blood during perfusion. pO2 in control untreated samples rose from 40.3+/-5.0 mm Hg perfusions to 100.4+/-12.5 mm Hg but remained at 66.3+/-6.3 mm Hg in sodium nitroprusside-treated blood (p<0.05). Our results did not show a significant effect of sodium nitroprusside in the modulation of platelet interaction with subendothelium. The marginal reduction in the thrombi height could be related to rheological interference of increased erythrocyte deformability." @default.
• W190461402 created "2016-06-24" @default.
• W190461402 creator A5011286690 @default.
• W190461402 creator A5012233931 @default.
• W190461402 creator A5037946459 @default.
• W190461402 creator A5056220797 @default.
• W190461402 creator A5066113900 @default.
• W190461402 creator A5082178339 @default.
• W190461402 date "2000-02-01" @default.
• W190461402 modified "2023-09-25" @default.
• W190461402 title "Antiplatelet Effects of Sodium Nitroprusside in Flowing Human Blood" @default.
• W190461402 cites W1603504851 @default.
• W190461402 cites W1868411085 @default.
• W190461402 cites W1873359408 @default.
• W190461402 cites W1974549029 @default.
• W190461402 cites W1984378104 @default.
• W190461402 cites W1993195400 @default.
• W190461402 cites W1994291636 @default.
• W190461402 cites W2007398897 @default.
• W190461402 cites W2011688402 @default.
• W190461402 cites W2020458159 @default.
• W190461402 cites W2021382982 @default.
• W190461402 cites W2022768087 @default.
• W190461402 cites W2027673613 @default.
• W190461402 cites W2030851349 @default.
• W190461402 cites W2035619942 @default.
• W190461402 cites W2036284239 @default.
• W190461402 cites W2038194254 @default.
• W190461402 cites W2048709704 @default.
• W190461402 cites W2054304532 @default.
• W190461402 cites W2065931676 @default.
• W190461402 cites W2067925728 @default.
• W190461402 cites W2072950908 @default.
• W190461402 cites W2074190390 @default.
• W190461402 cites W2078328099 @default.
• W190461402 cites W2084507858 @default.
• W190461402 cites W2087565398 @default.
• W190461402 cites W2108156759 @default.
• W190461402 cites W2132277524 @default.
• W190461402 cites W2132591359 @default.
• W190461402 cites W2138407815 @default.
• W190461402 cites W2291929112 @default.
• W190461402 cites W2318526809 @default.
• W190461402 cites W2338072936 @default.
• W190461402 cites W2403601321 @default.
• W190461402 cites W2405738162 @default.
• W190461402 cites W24998034 @default.
• W190461402 cites W82619170 @default.
• W190461402 doi "https://doi.org/10.1016/s0049-3848(99)00154-1" @default.
• W190461402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10674408" @default.
• W190461402 hasPublicationYear "2000" @default.
• W190461402 type Work @default.
• W190461402 sameAs 190461402 @default.
• W190461402 citedByCount "4" @default.
• W190461402 crossrefType "journal-article" @default.
• W190461402 hasAuthorship W190461402A5011286690 @default.
• W190461402 hasAuthorship W190461402A5012233931 @default.
• W190461402 hasAuthorship W190461402A5037946459 @default.
• W190461402 hasAuthorship W190461402A5056220797 @default.
• W190461402 hasAuthorship W190461402A5066113900 @default.
• W190461402 hasAuthorship W190461402A5082178339 @default.
• W190461402 hasConcept C126322002 @default.
• W190461402 hasConcept C134018914 @default.
• W190461402 hasConcept C146957229 @default.
• W190461402 hasConcept C1621761 @default.
• W190461402 hasConcept C178790620 @default.
• W190461402 hasConcept C181199279 @default.
• W190461402 hasConcept C185592680 @default.
• W190461402 hasConcept C2778078955 @default.
• W190461402 hasConcept C2779610285 @default.
• W190461402 hasConcept C2780076745 @default.
• W190461402 hasConcept C519581460 @default.
• W190461402 hasConcept C537181965 @default.
• W190461402 hasConcept C55493867 @default.
• W190461402 hasConcept C71924100 @default.
• W190461402 hasConcept C89560881 @default.
• W190461402 hasConcept C98274493 @default.
• W190461402 hasConceptScore W190461402C126322002 @default.
• W190461402 hasConceptScore W190461402C134018914 @default.
• W190461402 hasConceptScore W190461402C146957229 @default.
• W190461402 hasConceptScore W190461402C1621761 @default.
• W190461402 hasConceptScore W190461402C178790620 @default.
• W190461402 hasConceptScore W190461402C181199279 @default.
• W190461402 hasConceptScore W190461402C185592680 @default.
• W190461402 hasConceptScore W190461402C2778078955 @default.
• W190461402 hasConceptScore W190461402C2779610285 @default.
• W190461402 hasConceptScore W190461402C2780076745 @default.
• W190461402 hasConceptScore W190461402C519581460 @default.
• W190461402 hasConceptScore W190461402C537181965 @default.
• W190461402 hasConceptScore W190461402C55493867 @default.
• W190461402 hasConceptScore W190461402C71924100 @default.
• W190461402 hasConceptScore W190461402C89560881 @default.
• W190461402 hasConceptScore W190461402C98274493 @default.
• W190461402 hasLocation W1904614021 @default.
• W190461402 hasLocation W1904614022 @default.
• W190461402 hasOpenAccess W190461402 @default.
• W190461402 hasPrimaryLocation W1904614021 @default.
• W190461402 hasRelatedWork W1603504851 @default.
• W190461402 hasRelatedWork W1969990715 @default.
• W190461402 hasRelatedWork W1972467955 @default.

• next