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• W1904689509 abstract "Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. Increasing knowledge of the pathophysiology of FSHD has stimulated interest in developing biomarkers of disease severity.Two groups of MRI scans were analyzed: whole-body scans from 13 subjects with FSHD; and upper and lower extremity scans from 34 subjects with FSHD who participated in the MYO-029 clinical trial. Muscles were scored for fat infiltration and edema-like changes. Fat infiltration scores were compared with muscle strength and function.The analysis revealed a distinctive pattern of both frequent muscle involvement and frequent sparing in FSHD. Averaged fat infiltration scores for muscle groups in the legs correlated with quantitative muscle strength and 10-meter walk times.Advances in MRI technology allow for acquisition of rapid, high-quality, whole-body imaging in diffuse muscle disease. This technique offers a promising disease biomarker in FSHD and other muscle diseases." @default.
• W1904689509 created "2016-06-24" @default.
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• W1904689509 date "2015-03-31" @default.
• W1904689509 modified "2023-10-03" @default.
• W1904689509 title "Whole-body magnetic resonance imaging evaluation of facioscapulohumeral muscular dystrophy" @default.
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• W1904689509 doi "https://doi.org/10.1002/mus.24569" @default.
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