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• W1904833587 abstract "To investigate the association between duration of rupture of membranes (ROM) and mother-to-child HIV transmission (MTCT) rates in the era of combination antiretroviral therapy (cART).The National Study of HIV in Pregnancy and Childhood (NSHPC) undertakes comprehensive population-based surveillance of HIV in pregnant women and children.UK and Ireland.A cohort of 2398 singleton pregnancies delivered vaginally, or by emergency caesarean section, in women on cART in pregnancy during the period 2007-2012 with information on duration of ROM; HIV infection status was available for 1898 infants.Descriptive analysis of NSHPC data.Rates of MTCT.In 2116 pregnancies delivered at term, the median duration of ROM was 3 hours 30 minutes (interquartile range, IQR 1-8 hours). The overall MTCT rate for women delivering at term with duration of ROM ≥4 hours was 0.64% compared with 0.34% for ROM <4 hours, with no significant difference between the groups (OR 1.90, 95% CI 0.45-7.97). In women delivering at term with a viral load of <50 copies/ml, there was no evidence of a difference in MTCT rates with duration of ROM ≥4 hours, compared with <4 hours (0.14% for ≥4 hours versus 0.12% for <4 hour; OR 1.14, 95% CI 0.07-18.27). Among infants born preterm with infection status available, there were no transmissions in 163 deliveries where the maternal viral load was <50 copies/ml.No association was found between duration of ROM and MTCT in women taking cART.Rupture of membranes of more than 4 hours is not associated with MTCT of HIV in women on effective ART delivering at term." @default.
• W1904833587 created "2016-06-24" @default.
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• W1904833587 date "2015-05-22" @default.
• W1904833587 modified "2023-10-10" @default.
• W1904833587 title "Duration of ruptured membranes and mother‐to‐child <scp>HIV</scp> transmission: a prospective population‐based surveillance study" @default.
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• W1904833587 doi "https://doi.org/10.1111/1471-0528.13442" @default.
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