FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1904875888> ?p ?o ?g. }

• W1904875888 endingPage "1037" @default.
• W1904875888 startingPage "1030" @default.
• W1904875888 abstract "Glial fibrillary acidic protein (GFAP) is an intermediate-filament protein expressed abundantly and almost exclusively in astrocytes of the CNS. We are studying transcriptional regulation of the GFAP gene to gain insight into astrocyte function and also to develop an astrocyte- specific expression system for manipulating brain physiology. In this work, we have produced transgenic mice carrying the bacterial lacZ reporter gene linked to a 2.2 kilobase 5′-flanking sequence derived from the human GFAP gene that previously was shown to direct astrocyte- specific transcription in cultured cells. We report that this promoter directs expression to astrocytes in the CNS. In addition, the upregulation of GFAP gene activity that follows injury to the brain was mimicked by the transgene. One of the transgenes was found to be X- linked and appeared to undergo the usual random inactivation that achieves gene dosage compensation in females. The brains of hemizygous females stained uniformly rather than displaying mosaic patches, indicating that astrocytes intermingle following their formation. The specific expression of the GFAP-lacZ transgene means that it is now possible to target expression of other heterologous genes to astrocytes in vivo, and to study the mechanisms for reactive gliosis at the DNA level." @default.
• W1904875888 created "2016-06-24" @default.
• W1904875888 creator A5001955231 @default.
• W1904875888 creator A5005531623 @default.
• W1904875888 creator A5033152058 @default.
• W1904875888 creator A5043559536 @default.
• W1904875888 creator A5080356197 @default.
• W1904875888 date "1994-03-01" @default.
• W1904875888 modified "2023-10-16" @default.
• W1904875888 title "GFAP promoter directs astrocyte-specific expression in transgenic mice" @default.
• W1904875888 cites W1487222554 @default.
• W1904875888 cites W1592789336 @default.
• W1904875888 cites W1808154214 @default.
• W1904875888 cites W1964283168 @default.
• W1904875888 cites W1964867024 @default.
• W1904875888 cites W1965718695 @default.
• W1904875888 cites W1968074776 @default.
• W1904875888 cites W1973434441 @default.
• W1904875888 cites W1978811180 @default.
• W1904875888 cites W1979474933 @default.
• W1904875888 cites W1998502389 @default.
• W1904875888 cites W2005021221 @default.
• W1904875888 cites W2011204636 @default.
• W1904875888 cites W2019956654 @default.
• W1904875888 cites W2023402827 @default.
• W1904875888 cites W2030770860 @default.
• W1904875888 cites W2036957298 @default.
• W1904875888 cites W2040913237 @default.
• W1904875888 cites W2041163373 @default.
• W1904875888 cites W2044597962 @default.
• W1904875888 cites W2047755130 @default.
• W1904875888 cites W2056521724 @default.
• W1904875888 cites W2062325533 @default.
• W1904875888 cites W2064368446 @default.
• W1904875888 cites W2072812579 @default.
• W1904875888 cites W2074913197 @default.
• W1904875888 cites W2077683978 @default.
• W1904875888 cites W2084099920 @default.
• W1904875888 cites W2089390647 @default.
• W1904875888 cites W2089549370 @default.
• W1904875888 cites W2113161487 @default.
• W1904875888 cites W2132804961 @default.
• W1904875888 cites W2165932111 @default.
• W1904875888 cites W2405827071 @default.
• W1904875888 cites W24659260 @default.
• W1904875888 cites W92814390 @default.
• W1904875888 doi "https://doi.org/10.1523/jneurosci.14-03-01030.1994" @default.
• W1904875888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6577554" @default.
• W1904875888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8120611" @default.
• W1904875888 hasPublicationYear "1994" @default.
• W1904875888 type Work @default.
• W1904875888 sameAs 1904875888 @default.
• W1904875888 citedByCount "449" @default.
• W1904875888 countsByYear W19048758882012 @default.
• W1904875888 countsByYear W19048758882013 @default.
• W1904875888 countsByYear W19048758882014 @default.
• W1904875888 countsByYear W19048758882015 @default.
• W1904875888 countsByYear W19048758882016 @default.
• W1904875888 countsByYear W19048758882017 @default.
• W1904875888 countsByYear W19048758882018 @default.
• W1904875888 countsByYear W19048758882019 @default.
• W1904875888 countsByYear W19048758882020 @default.
• W1904875888 countsByYear W19048758882021 @default.
• W1904875888 countsByYear W19048758882022 @default.
• W1904875888 countsByYear W19048758882023 @default.
• W1904875888 crossrefType "journal-article" @default.
• W1904875888 hasAuthorship W1904875888A5001955231 @default.
• W1904875888 hasAuthorship W1904875888A5005531623 @default.
• W1904875888 hasAuthorship W1904875888A5033152058 @default.
• W1904875888 hasAuthorship W1904875888A5043559536 @default.
• W1904875888 hasAuthorship W1904875888A5080356197 @default.
• W1904875888 hasBestOaLocation W19048758881 @default.
• W1904875888 hasConcept C102230213 @default.
• W1904875888 hasConcept C104317684 @default.
• W1904875888 hasConcept C141035611 @default.
• W1904875888 hasConcept C150194340 @default.
• W1904875888 hasConcept C153911025 @default.
• W1904875888 hasConcept C161733203 @default.
• W1904875888 hasConcept C165864922 @default.
• W1904875888 hasConcept C169760540 @default.
• W1904875888 hasConcept C203014093 @default.
• W1904875888 hasConcept C204232928 @default.
• W1904875888 hasConcept C2777542381 @default.
• W1904875888 hasConcept C2780115692 @default.
• W1904875888 hasConcept C2780495277 @default.
• W1904875888 hasConcept C529278444 @default.
• W1904875888 hasConcept C54355233 @default.
• W1904875888 hasConcept C86803240 @default.
• W1904875888 hasConcept C95444343 @default.
• W1904875888 hasConceptScore W1904875888C102230213 @default.
• W1904875888 hasConceptScore W1904875888C104317684 @default.
• W1904875888 hasConceptScore W1904875888C141035611 @default.
• W1904875888 hasConceptScore W1904875888C150194340 @default.
• W1904875888 hasConceptScore W1904875888C153911025 @default.
• W1904875888 hasConceptScore W1904875888C161733203 @default.
• W1904875888 hasConceptScore W1904875888C165864922 @default.
• W1904875888 hasConceptScore W1904875888C169760540 @default.
• W1904875888 hasConceptScore W1904875888C203014093 @default.

• next