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- W1904928675 abstract "This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD." @default.
- W1904928675 created "2016-06-24" @default.
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- W1904928675 date "2015-06-01" @default.
- W1904928675 modified "2023-10-10" @default.
- W1904928675 title "The<i>n</i>-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an<i>In Vivo</i>Model of Amyloid-<i>β</i>-Induced Alzheimer's Disease" @default.
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- W1904928675 doi "https://doi.org/10.1089/jmf.2014.3292" @default.
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