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• W1904962657 abstract "Chemoattraction is defined as the unidirectional movement of a cell, in response to a chemical gradient of ligands. During chemoattraction, cells move in the direction from a low to a high concentration of the chemoattractant. Chemoattraction is called ‘chemotaxis’ when the ligand gradient is soluble and ‘haptotaxis’ when this gradient is bound to the substrate. Chemoattraction plays a fundamental role in the regulation of the precise location of leucocytes during the immune response and consequently is fundamental for the adequate functioning of leucocytes in the immune system. Classical chemoattractants and chemokines use guanine nucleotide-binding protein-coupled seven-transmembrane-spanning receptors to relay intracellular signals that regulate chemoattraction. Apart from chemoattraction, chemoattractants and chemoattractant receptors may play additional functions, scavenging, transcytosis or even antimicrobial activities that could also importantly contribute to a correct immune response. Key Concepts: Chemoattraction is defined as the unidirectional movement of a cell, in response to a chemical gradient of ligands. Chemoattractive factor constitutes a diverse group of chemicals, including lipids, formylated peptides, proteolytic fragments of complement proteins and chemokines, with chemoattractive properties. Alterations in the expression or function of chemokine receptors are involved in a variety of human pathologies. Chemokines are small secreted proteins (8–14 kDa) that display a similar tertiary structure and potent chemoattractive abilities. Chemokines regulate a variety of cell functions in addition to chemotaxis." @default.
• W1904962657 created "2016-06-24" @default.
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• W1904962657 date "2013-09-06" @default.
• W1904962657 modified "2023-10-18" @default.
• W1904962657 title "Chemoattraction: Basic Concepts and Role in the Immune Response" @default.
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• W1904962657 doi "https://doi.org/10.1002/9780470015902.a0000507.pub3" @default.
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