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- W1905150660 endingPage "295" @default.
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- W1905150660 abstract "The purpose of this study was to study the expression of endothelin-1 (ET-1) and its receptors ETA and ETB in normal human gingiva and cyclosporin-induced gingival fibroblasts.Gingival samples were collected from eight normal healthy individuals, eight patients with periodontitis, and eight patients with cyclosporin A (CsA)-induced gingival overgrowth. Total RNA was extracted from tissue samples, and reverse transcriptase-polymerase chain reaction was performed for ET-1, ETA, and ETB. ET-1 protein was estimated from the tissues by enzyme-linked immunosorbent assay. The expression of ET-1 and its receptors was also examined in gingival fibroblast cells treated with CsA.ET-1 mRNA expression was significantly higher in patients with CsA-induced gingival overgrowth (P <0.001) than in patients with periodontitis and the controls. ETA mRNA was expressed more than the ETB in all examined samples. In human gingival fibroblasts, ET-1 expression was increased with CsA incorporation compared to controls (P <0.001).These results suggest that CsA can modulate the expression of ET-1 in gingival fibroblasts and CsA-induced gingival overgrowth." @default.
- W1905150660 created "2016-06-24" @default.
- W1905150660 creator A5008237247 @default.
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- W1905150660 date "2007-02-01" @default.
- W1905150660 modified "2023-10-15" @default.
- W1905150660 title "Endothelin‐1 and Its Receptors ET<sub>A</sub> and ET<sub>B</sub> in Drug‐Induced Gingival Overgrowth" @default.
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- W1905150660 doi "https://doi.org/10.1902/jop.2007.060172" @default.
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