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- W1905165811 abstract "Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains. QTL mapping of backcross [(A/J × C3H/HeJ) × C3H/HeJ] progeny ( n = 137–227 informative mice for markers tested) revealed two significant linkages to loci on chromosomes 6 and 7. The QTL on chromosome 6 confirms the previous report by others of a linkage in this region in the same genetic backgrounds; the second QTL, on chromosome 7, represents a novel locus. In addition, we obtained suggestive evidence for linkage (logarithm of odds ratio = 1.7) on chromosome 17, which lies in the same region previously identified in a cross between A/J and C57BL/6J mice. Airway responsiveness in a cross between A/J and C3H/HeJ mice is under the control of at least two major genetic loci, with evidence for a third locus that has been previously implicated in an A/J and C57BL/6J cross; this indicates that multiple genetic factors control the expression of this phenotype." @default.
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- W1905165811 date "1999-12-01" @default.
- W1905165811 modified "2023-10-16" @default.
- W1905165811 title "Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice" @default.
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- W1905165811 doi "https://doi.org/10.1152/ajplung.1999.277.6.l1118" @default.
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