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• W1905192943 startingPage "1421" @default.
• W1905192943 abstract "Citrus aurantium (bitter orange) extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management as well as in sports performance products. However, questions are raised frequently regarding the safety of these ingredients. The potential inherent dangers associated with the use of products containing C. aurantium extract are frequently touted, while conversely, millions of doses of dietary supplements have been consumed by possibly millions of individuals in recent years. Furthermore, millions of people consume on a daily basis various juices and food products from Citrus species that contain p-synephrine. This review summarizes current information regarding the safety of C. aurantium (bitter orange) extract and p-synephrine based on human, animal and in vitro assessments as well as receptor binding and mechanistic studies. The data indicate that based on current knowledge, the use of bitter orange extract and p-synephrine appears to be exceedingly safe with no serious adverse effects being directly attributable to these ingredients." @default.
• W1905192943 created "2016-06-24" @default.
• W1905192943 creator A5034701678 @default.
• W1905192943 creator A5047768346 @default.
• W1905192943 creator A5062695970 @default.
• W1905192943 date "2011-04-08" @default.
• W1905192943 modified "2023-10-05" @default.
• W1905192943 title "The Safety of <i>Citrus aurantium</i> (Bitter Orange) and its Primary Protoalkaloid <i>p</i> -Synephrine" @default.
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• W1905192943 doi "https://doi.org/10.1002/ptr.3490" @default.
• W1905192943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21480414" @default.
• W1905192943 hasPublicationYear "2011" @default.
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