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• W1905249904 abstract "Summary During pathogenesis, M ycobacterium tuberculosis ( Mtb ) colonizes environments, such as the macrophage or necrotic granuloma, that are acidic and rich in cholesterol and fatty acids. The goal of this study was to examine how acidic pH and available carbon sources interact to regulate Mtb physiology. Here we report that Mtb growth at acidic pH requires host‐associated carbon sources that function at the intersection of glycolysis and the TCA cycle, such as pyruvate, acetate, oxaloacetate and cholesterol. In contrast, in other tested carbon sources, Mtb fully arrests its growth at acidic pH and establishes a state of non‐replicating persistence. Growth‐arrested Mtb is resuscitated by the addition of pyruvate suggesting that growth arrest is due to a pH ‐dependent checkpoint on metabolism. Additionally, we demonstrate that the phoPR two‐component regulatory system is required to slow Mtb growth at acidic pH and functions to maintain redox homeostasis. Transcriptional profiling and functional metabolic studies demonstrate that signals from acidic pH and carbon source are integrated to remodel pathways associated with anaplerotic central metabolism, lipid anabolism and the regeneration of oxidized cofactors. Because phoPR is required for Mtb virulence in animals, we suggest that pH ‐driven adaptation may be critical to Mtb pathogenesis." @default.
• W1905249904 created "2016-06-24" @default.
• W1905249904 creator A5000135987 @default.
• W1905249904 creator A5068460948 @default.
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• W1905249904 date "2014-07-13" @default.
• W1905249904 modified "2023-10-17" @default.
• W1905249904 title "Slow growth of<i>M</i><i>ycobacterium tuberculosis</i>at acidic pH is regulated by<i>phoPR</i>and host-associated carbon sources" @default.
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• W1905249904 doi "https://doi.org/10.1111/mmi.12688" @default.
• W1905249904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177513" @default.
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