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• W1905286104 abstract "Miura, M., Morris, G. M., Micca, P. L., Lombardo, D. T., Youngs, K. M., Kalef-Ezra, J. A., Hoch, D. A., Slatkin, D. N., Ma, R. and Coderre, J. A. Boron Neutron Capture Therapy of a Murine Tumor using a Lipophilic Carboranyltetraphenylporphyrin.The first control of a malignant tumor in vivo by porphyrin- mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary carcinomas, boron uptake using a single injection of either p-boronophenylalanine (BPA) or mercaptoundecahydrododecaborane (BSH) was compared with either a single injection or multiple injections of the carboranylporphyrin CuTCPH. The BSH and BPA doses used were comparable to the highest doses of these compounds previously administered in a single injection to rodents. For BNCT, boron concentrations averaged 85 μg 10B/g in the tumor and 4 μg 10B/g in blood 2 days after the last of six injections (over 32 h) that delivered a total of 190 μg CuTCPH/g body weight. During a single 15, 20, 25 or 30 MW-min exposure to the thermalized neutron beam of the Brookhaven Medical Research Reactor, a tumor received average absorbed doses of approximately 39, 52, 66 or 79 Gy, respectively. A long-term (>200 days) tumor control rate of 71% was achieved at a dose of 66 Gy with minimal damage to the leg. Equivalent long-term tumor control by a single exposure to 42 Gy X rays was achieved, but with greater damage to the irradiated leg." @default.
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• W1905286104 date "2001-04-01" @default.
• W1905286104 modified "2023-10-10" @default.
• W1905286104 title "Boron Neutron Capture Therapy of a Murine Mammary Carcinoma using a Lipophilic Carboranyltetraphenylporphyrin¹" @default.
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• W1905286104 doi "https://doi.org/10.1667/0033-7587(2001)155[0603:bnctoa]2.0.co;2" @default.
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