FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1905286773> ?p ?o ?g. }

• W1905286773 endingPage "1667" @default.
• W1905286773 startingPage "1662" @default.
• W1905286773 abstract "Although extracts of garlic inhibit cholesterol biosynthesis in cultured hepatocytes, the inhibitory components of garlic and the site or sites of inhibition in the cholesterol biosynthetic pathway have not been established. To elucidate potential mechanisms of inhibition, we examined the effect of fresh garlic extract and 16 water- or lipid-soluble compounds derived from garlic on purified recombinant human squalene monooxygenase. Squalene monooxygenase catalyzes the second and likely rate-limiting step in the downstream pathway for cholesterol biosynthesis. A 50% inhibitory concentration (IC(50)) of squalene epoxidation was achieved with 1 g/L of fresh garlic extract; of the 16 garlic compounds tested, only selenocystine (IC(50) = 65 micromol/L), S-allylcysteine (IC(50) = 110 micromol/L), alliin (IC(50) = 120 micromol/L), diallyl trisulfide (IC(50) = 195 micromol/L), and diallyl disulfide (IC(50) = 400 micromol/L) substantially inhibited the enzyme. Kinetic analysis showed that the inhibition by garlic and by these compounds was slow and irreversible, suggestive of covalent binding to the enzyme; the ability of thiol-containing compounds such as glutathione and 2,3-dimercaptopropanol to prevent and reverse the inhibition indicated that the garlic compounds were reacting with sulfhydryl groups on the protein. Dithiols were better reversal agents than monothiols, further suggesting that these inhibitors bind to the proposed vicinal sulfhydryls present on this enzyme. These results indicate that squalene monooxygenase may be one of the target enzymes through which garlic inhibits cholesterol biosynthesis." @default.
• W1905286773 created "2016-06-24" @default.
• W1905286773 creator A5055797259 @default.
• W1905286773 creator A5061237297 @default.
• W1905286773 date "2001-06-01" @default.
• W1905286773 modified "2023-10-01" @default.
• W1905286773 title "Garlic and Garlic-Derived Compounds Inhibit Human Squalene Monooxygenase" @default.
• W1905286773 cites W1579297624 @default.
• W1905286773 cites W1601956553 @default.
• W1905286773 cites W1791275059 @default.
• W1905286773 cites W1809123538 @default.
• W1905286773 cites W1896955848 @default.
• W1905286773 cites W1979608829 @default.
• W1905286773 cites W1992980054 @default.
• W1905286773 cites W2008086015 @default.
• W1905286773 cites W2011192012 @default.
• W1905286773 cites W2013774949 @default.
• W1905286773 cites W2019226150 @default.
• W1905286773 cites W2036000847 @default.
• W1905286773 cites W2038768365 @default.
• W1905286773 cites W2050316877 @default.
• W1905286773 cites W2061237023 @default.
• W1905286773 cites W2061388149 @default.
• W1905286773 cites W2063132006 @default.
• W1905286773 cites W2067670440 @default.
• W1905286773 cites W2068652514 @default.
• W1905286773 cites W2084670726 @default.
• W1905286773 cites W2087169447 @default.
• W1905286773 cites W2090598474 @default.
• W1905286773 cites W2110468275 @default.
• W1905286773 cites W2117051152 @default.
• W1905286773 cites W2119415491 @default.
• W1905286773 cites W2123730816 @default.
• W1905286773 cites W2130257542 @default.
• W1905286773 cites W2172222575 @default.
• W1905286773 cites W2174559065 @default.
• W1905286773 cites W2176144905 @default.
• W1905286773 doi "https://doi.org/10.1093/jn/131.6.1662" @default.
• W1905286773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11385050" @default.
• W1905286773 hasPublicationYear "2001" @default.
• W1905286773 type Work @default.
• W1905286773 sameAs 1905286773 @default.
• W1905286773 citedByCount "129" @default.
• W1905286773 countsByYear W19052867732012 @default.
• W1905286773 countsByYear W19052867732013 @default.
• W1905286773 countsByYear W19052867732014 @default.
• W1905286773 countsByYear W19052867732015 @default.
• W1905286773 countsByYear W19052867732016 @default.
• W1905286773 countsByYear W19052867732017 @default.
• W1905286773 countsByYear W19052867732018 @default.
• W1905286773 countsByYear W19052867732019 @default.
• W1905286773 countsByYear W19052867732020 @default.
• W1905286773 countsByYear W19052867732021 @default.
• W1905286773 countsByYear W19052867732022 @default.
• W1905286773 countsByYear W19052867732023 @default.
• W1905286773 crossrefType "journal-article" @default.
• W1905286773 hasAuthorship W1905286773A5055797259 @default.
• W1905286773 hasAuthorship W1905286773A5061237297 @default.
• W1905286773 hasBestOaLocation W19052867731 @default.
• W1905286773 hasConcept C13002179 @default.
• W1905286773 hasConcept C181199279 @default.
• W1905286773 hasConcept C185592680 @default.
• W1905286773 hasConcept C190283241 @default.
• W1905286773 hasConcept C2776488830 @default.
• W1905286773 hasConcept C2776703722 @default.
• W1905286773 hasConcept C2781220098 @default.
• W1905286773 hasConcept C2911096038 @default.
• W1905286773 hasConcept C31903555 @default.
• W1905286773 hasConcept C526171541 @default.
• W1905286773 hasConcept C538909803 @default.
• W1905286773 hasConcept C553450214 @default.
• W1905286773 hasConcept C55493867 @default.
• W1905286773 hasConcept C85411794 @default.
• W1905286773 hasConceptScore W1905286773C13002179 @default.
• W1905286773 hasConceptScore W1905286773C181199279 @default.
• W1905286773 hasConceptScore W1905286773C185592680 @default.
• W1905286773 hasConceptScore W1905286773C190283241 @default.
• W1905286773 hasConceptScore W1905286773C2776488830 @default.
• W1905286773 hasConceptScore W1905286773C2776703722 @default.
• W1905286773 hasConceptScore W1905286773C2781220098 @default.
• W1905286773 hasConceptScore W1905286773C2911096038 @default.
• W1905286773 hasConceptScore W1905286773C31903555 @default.
• W1905286773 hasConceptScore W1905286773C526171541 @default.
• W1905286773 hasConceptScore W1905286773C538909803 @default.
• W1905286773 hasConceptScore W1905286773C553450214 @default.
• W1905286773 hasConceptScore W1905286773C55493867 @default.
• W1905286773 hasConceptScore W1905286773C85411794 @default.
• W1905286773 hasIssue "6" @default.
• W1905286773 hasLocation W19052867731 @default.
• W1905286773 hasLocation W19052867732 @default.
• W1905286773 hasOpenAccess W1905286773 @default.
• W1905286773 hasPrimaryLocation W19052867731 @default.
• W1905286773 hasRelatedWork W1856368922 @default.
• W1905286773 hasRelatedWork W1905286773 @default.
• W1905286773 hasRelatedWork W1992907029 @default.
• W1905286773 hasRelatedWork W2039638767 @default.
• W1905286773 hasRelatedWork W2040560698 @default.
• W1905286773 hasRelatedWork W2358858385 @default.

• next