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- W1905471660 abstract "Abstract The X and Y chromosomes of the platyfish (Xiphophorus maculatus) contain a region that encodes several important traits, including the determination of sex, pigment pattern formation, and predisposition to develop malignant melanoma. Several sex-chromosomal crossovers were identified in this region. As the melanoma-inducing oncogene Xmrk is the only molecularly identified constituent, its genomic organization on both sex chromosomes was analyzed in detail. Using X and Y allele-specific sequence differences a high proportion of the crossovers was found to be intragenic in the oncogene Xmrk, concentrating in the extracellular domain-encoding region. The genetic and molecular data allowed establishment of an order of loci over ∼0.6 cM. It further revealed a sequence located within several kilobases of the extracellular domain-encoding region of Xmrk that regulates overexpression of the oncogene." @default.
- W1905471660 created "2016-06-24" @default.
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- W1905471660 date "1999-02-01" @default.
- W1905471660 modified "2023-10-15" @default.
- W1905471660 title "Intragenic Sex-Chromosomal Crossovers of Xmrk Oncogene Alleles Affect Pigment Pattern Formation and the Severity of Melanoma in Xiphophorus" @default.
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- W1905471660 doi "https://doi.org/10.1093/genetics/151.2.773" @default.
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