Matches in SemOpenAlex for { <https://semopenalex.org/work/W1905807479> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1905807479 endingPage "227" @default.
- W1905807479 startingPage "205" @default.
- W1905807479 abstract "This chapter raises many of the unresolved biostatistical issues in the neuroemergency clinical trials arena. Neuroemergency clinical trials are complex activities, and enrollment and study operations can be difficult to manage. The diseases and disorders involved may require that significant time elapses before having reliable estimates of clinical outcomes. This has significant impact on the planning for such studies where follow-up periods may require 6 to 12 months. A problem with recent failed trials in neuroemergencies is at least partially a function of the limited supportive preclinical data available to support the clinical development program. The limitations of these data can range from adequacy of drug levels in the target organ, assumptions about the biological activity, to the magnitude of the expected effects on the efficacy endpoints of choice. Current statistical issues in neuroemergency clinical trials relating to data analysis include the precision of outcome measures, multiplicity of endpoints, selection biases, and the effects of adjustments to data and subsequent interpretations. Data analysis planning for neuroemergency clinical trials must weigh which analysis populations are relevant. In defining appropriate data analysis populations, both scientific and regulatory concerns are at issue." @default.
- W1905807479 created "2016-06-24" @default.
- W1905807479 creator A5074963669 @default.
- W1905807479 date "2006-01-01" @default.
- W1905807479 modified "2023-09-26" @default.
- W1905807479 title "Biostatistical Issues in Neuroemergency Clinical Trials" @default.
- W1905807479 cites W145468704 @default.
- W1905807479 cites W1543216141 @default.
- W1905807479 cites W1879823279 @default.
- W1905807479 cites W1969661146 @default.
- W1905807479 cites W1982375973 @default.
- W1905807479 cites W1986222379 @default.
- W1905807479 cites W1986301617 @default.
- W1905807479 cites W1989883289 @default.
- W1905807479 cites W2004667116 @default.
- W1905807479 cites W2006667907 @default.
- W1905807479 cites W2016656772 @default.
- W1905807479 cites W2042603438 @default.
- W1905807479 cites W2045364056 @default.
- W1905807479 cites W2071381562 @default.
- W1905807479 cites W2072968785 @default.
- W1905807479 cites W2080675410 @default.
- W1905807479 cites W2090612611 @default.
- W1905807479 cites W2098889168 @default.
- W1905807479 cites W2119835440 @default.
- W1905807479 cites W2123830992 @default.
- W1905807479 cites W2138839431 @default.
- W1905807479 cites W2155074770 @default.
- W1905807479 cites W2155949904 @default.
- W1905807479 cites W2161760321 @default.
- W1905807479 cites W2166043386 @default.
- W1905807479 cites W2169079203 @default.
- W1905807479 cites W2279685009 @default.
- W1905807479 cites W2284004651 @default.
- W1905807479 cites W3045153201 @default.
- W1905807479 cites W3188550453 @default.
- W1905807479 cites W2009776004 @default.
- W1905807479 doi "https://doi.org/10.1016/b978-012648082-5/50013-7" @default.
- W1905807479 hasPublicationYear "2006" @default.
- W1905807479 type Work @default.
- W1905807479 sameAs 1905807479 @default.
- W1905807479 citedByCount "1" @default.
- W1905807479 crossrefType "book-chapter" @default.
- W1905807479 hasAuthorship W1905807479A5074963669 @default.
- W1905807479 hasConcept C112930515 @default.
- W1905807479 hasConcept C142724271 @default.
- W1905807479 hasConcept C144237770 @default.
- W1905807479 hasConcept C148220186 @default.
- W1905807479 hasConcept C148482608 @default.
- W1905807479 hasConcept C177713679 @default.
- W1905807479 hasConcept C19527891 @default.
- W1905807479 hasConcept C2522767166 @default.
- W1905807479 hasConcept C2780035454 @default.
- W1905807479 hasConcept C2992672634 @default.
- W1905807479 hasConcept C33923547 @default.
- W1905807479 hasConcept C41008148 @default.
- W1905807479 hasConcept C535046627 @default.
- W1905807479 hasConcept C64903051 @default.
- W1905807479 hasConcept C71924100 @default.
- W1905807479 hasConcept C98274493 @default.
- W1905807479 hasConceptScore W1905807479C112930515 @default.
- W1905807479 hasConceptScore W1905807479C142724271 @default.
- W1905807479 hasConceptScore W1905807479C144237770 @default.
- W1905807479 hasConceptScore W1905807479C148220186 @default.
- W1905807479 hasConceptScore W1905807479C148482608 @default.
- W1905807479 hasConceptScore W1905807479C177713679 @default.
- W1905807479 hasConceptScore W1905807479C19527891 @default.
- W1905807479 hasConceptScore W1905807479C2522767166 @default.
- W1905807479 hasConceptScore W1905807479C2780035454 @default.
- W1905807479 hasConceptScore W1905807479C2992672634 @default.
- W1905807479 hasConceptScore W1905807479C33923547 @default.
- W1905807479 hasConceptScore W1905807479C41008148 @default.
- W1905807479 hasConceptScore W1905807479C535046627 @default.
- W1905807479 hasConceptScore W1905807479C64903051 @default.
- W1905807479 hasConceptScore W1905807479C71924100 @default.
- W1905807479 hasConceptScore W1905807479C98274493 @default.
- W1905807479 hasLocation W19058074791 @default.
- W1905807479 hasOpenAccess W1905807479 @default.
- W1905807479 hasPrimaryLocation W19058074791 @default.
- W1905807479 hasRelatedWork W1994858058 @default.
- W1905807479 hasRelatedWork W2001558765 @default.
- W1905807479 hasRelatedWork W2070273743 @default.
- W1905807479 hasRelatedWork W2071907783 @default.
- W1905807479 hasRelatedWork W2088663266 @default.
- W1905807479 hasRelatedWork W2319635624 @default.
- W1905807479 hasRelatedWork W2411193972 @default.
- W1905807479 hasRelatedWork W2470067656 @default.
- W1905807479 hasRelatedWork W2753756048 @default.
- W1905807479 hasRelatedWork W4206732464 @default.
- W1905807479 isParatext "false" @default.
- W1905807479 isRetracted "false" @default.
- W1905807479 magId "1905807479" @default.
- W1905807479 workType "book-chapter" @default.