FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906021965> ?p ?o ?g. }

• W1906021965 endingPage "302" @default.
• W1906021965 startingPage "297" @default.
• W1906021965 abstract "Insulin and insulin-like growth factor 1 (IGF-1) are evolutionarily conserved hormonal signalling molecules, which influence a wide array of physiological functions including metabolism, growth and development. Using genetic mouse studies, both insulin and IGF-1 have been shown to be anabolic agents in osteoblasts and bone development primarily through the activation of Akt and ERK signalling pathways. In this study, we examined the temporal signalling actions of insulin and IGF-1 on primary calvarial osteoblast growth and differentiation. First, we observed that the IGF-1 receptor expression decreases whereas insulin receptor expression increases during osteoblast differentiation. Subsequently, we show that although both insulin and IGF-1 promote osteoblast differentiation and mineralization in vitro, IGF-1, but not insulin, can induce osteoblast proliferation. The IGF-1-induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1-mediated cell proliferation was blocked by U0126, an MEK/MAPK inhibitor, or LY294002, a PI3-kinase inhibitor. Osteocalcin, an osteoblast-specific protein whose expression corresponds with osteoblast differentiation, was increased in a dose- and time-dependent manner after insulin treatment, whereas it was decreased with IGF-1 treatment. Moreover, insulin treatment dramatically induced osteocalcin promoter activity, whereas IGF-1 treatment significantly inhibited it, indicating direct effect of insulin on osteocalcin synthesis. Copyright © 2012 John Wiley & Sons, Ltd." @default.
• W1906021965 created "2016-06-24" @default.
• W1906021965 creator A5000045667 @default.
• W1906021965 creator A5002989556 @default.
• W1906021965 creator A5033388802 @default.
• W1906021965 creator A5036850968 @default.
• W1906021965 creator A5044244957 @default.
• W1906021965 creator A5063650555 @default.
• W1906021965 creator A5079944579 @default.
• W1906021965 date "2012-01-17" @default.
• W1906021965 modified "2023-10-10" @default.
• W1906021965 title "Effects of insulin and insulin-like growth factor 1 on osteoblast proliferation and differentiation: differential signalling via Akt and ERK" @default.
• W1906021965 cites W1976718154 @default.
• W1906021965 cites W1984821835 @default.
• W1906021965 cites W1998493448 @default.
• W1906021965 cites W2008481699 @default.
• W1906021965 cites W2009416961 @default.
• W1906021965 cites W2013339414 @default.
• W1906021965 cites W2027609127 @default.
• W1906021965 cites W2028122458 @default.
• W1906021965 cites W2030455830 @default.
• W1906021965 cites W2039421524 @default.
• W1906021965 cites W2055454767 @default.
• W1906021965 cites W2069270043 @default.
• W1906021965 cites W2070624893 @default.
• W1906021965 cites W2073144089 @default.
• W1906021965 cites W2096064481 @default.
• W1906021965 cites W2148194935 @default.
• W1906021965 cites W2155907836 @default.
• W1906021965 cites W4239716791 @default.
• W1906021965 cites W4244677853 @default.
• W1906021965 doi "https://doi.org/10.1002/cbf.2801" @default.
• W1906021965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22249904" @default.
• W1906021965 hasPublicationYear "2012" @default.
• W1906021965 type Work @default.
• W1906021965 sameAs 1906021965 @default.
• W1906021965 citedByCount "103" @default.
• W1906021965 countsByYear W19060219652012 @default.
• W1906021965 countsByYear W19060219652013 @default.
• W1906021965 countsByYear W19060219652014 @default.
• W1906021965 countsByYear W19060219652015 @default.
• W1906021965 countsByYear W19060219652016 @default.
• W1906021965 countsByYear W19060219652017 @default.
• W1906021965 countsByYear W19060219652018 @default.
• W1906021965 countsByYear W19060219652019 @default.
• W1906021965 countsByYear W19060219652020 @default.
• W1906021965 countsByYear W19060219652021 @default.
• W1906021965 countsByYear W19060219652022 @default.
• W1906021965 countsByYear W19060219652023 @default.
• W1906021965 crossrefType "journal-article" @default.
• W1906021965 hasAuthorship W1906021965A5000045667 @default.
• W1906021965 hasAuthorship W1906021965A5002989556 @default.
• W1906021965 hasAuthorship W1906021965A5033388802 @default.
• W1906021965 hasAuthorship W1906021965A5036850968 @default.
• W1906021965 hasAuthorship W1906021965A5044244957 @default.
• W1906021965 hasAuthorship W1906021965A5063650555 @default.
• W1906021965 hasAuthorship W1906021965A5079944579 @default.
• W1906021965 hasConcept C112446052 @default.
• W1906021965 hasConcept C126322002 @default.
• W1906021965 hasConcept C131075544 @default.
• W1906021965 hasConcept C134018914 @default.
• W1906021965 hasConcept C160160445 @default.
• W1906021965 hasConcept C170493617 @default.
• W1906021965 hasConcept C181199279 @default.
• W1906021965 hasConcept C185592680 @default.
• W1906021965 hasConcept C185967709 @default.
• W1906021965 hasConcept C202751555 @default.
• W1906021965 hasConcept C2775960820 @default.
• W1906021965 hasConcept C2777391703 @default.
• W1906021965 hasConcept C2778260815 @default.
• W1906021965 hasConcept C2779306644 @default.
• W1906021965 hasConcept C2780689927 @default.
• W1906021965 hasConcept C55493867 @default.
• W1906021965 hasConcept C57074206 @default.
• W1906021965 hasConcept C62478195 @default.
• W1906021965 hasConcept C71924100 @default.
• W1906021965 hasConcept C75217442 @default.
• W1906021965 hasConcept C86554907 @default.
• W1906021965 hasConcept C86803240 @default.
• W1906021965 hasConcept C95444343 @default.
• W1906021965 hasConceptScore W1906021965C112446052 @default.
• W1906021965 hasConceptScore W1906021965C126322002 @default.
• W1906021965 hasConceptScore W1906021965C131075544 @default.
• W1906021965 hasConceptScore W1906021965C134018914 @default.
• W1906021965 hasConceptScore W1906021965C160160445 @default.
• W1906021965 hasConceptScore W1906021965C170493617 @default.
• W1906021965 hasConceptScore W1906021965C181199279 @default.
• W1906021965 hasConceptScore W1906021965C185592680 @default.
• W1906021965 hasConceptScore W1906021965C185967709 @default.
• W1906021965 hasConceptScore W1906021965C202751555 @default.
• W1906021965 hasConceptScore W1906021965C2775960820 @default.
• W1906021965 hasConceptScore W1906021965C2777391703 @default.
• W1906021965 hasConceptScore W1906021965C2778260815 @default.
• W1906021965 hasConceptScore W1906021965C2779306644 @default.
• W1906021965 hasConceptScore W1906021965C2780689927 @default.
• W1906021965 hasConceptScore W1906021965C55493867 @default.
• W1906021965 hasConceptScore W1906021965C57074206 @default.
• W1906021965 hasConceptScore W1906021965C62478195 @default.

• next