FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906130536> ?p ?o ?g. }

• W1906130536 endingPage "487" @default.
• W1906130536 startingPage "478" @default.
• W1906130536 abstract "Gigante AD, Bond DJ, Lafer B, Lam RW, Young LT, Yatham LN. Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis. Bipolar Disord 2012: 14: 478–487. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objectives: Bipolar disorder (BD) is a common and highly disabling disease characterized by substantial cognitive and functional impairment. The exact neurobiological mechanisms underlying the expression of symptoms in this condition remain unknown but there is growing evidence that glutamate might play an important role. Using proton magnetic resonance spectroscopy (1H-MRS), a number of studies have examined brain glutamate/glutamine levels in patients with bipolar disorder, but they have produced conflicting results. The objective of this paper was to conduct a systematic review and meta-analysis of the literature on brain glutamate/glutamine in BD as measured by 1H-MRS. Methods: A Medline search for the period January 1980–April 2010 was conducted to identify published studies that used 1H-MRS to measure glutamate + glutamine (Glx), the Glx/creatine (Cr) ratio, glutamate (Glu), or the Glu/Cr ratio in any brain region in adult or child/adolescent patients with BD and healthy subjects. A meta-analysis of the pooled data was conducted. Results: BD patients were found to have increased Glx compared to healthy subjects when all brain areas were combined. This finding remained true in medicated and non-medicated patients, and in frontal brain areas in adults. There was a non-significant trend (p = 0.09) for an increase in whole-brain Glx/Cr and Glu in patients compared with healthy subjects. No significant difference was found in Glu/Cr. Conclusions: The results of this meta-analysis suggest that brain Glx levels are elevated in BD patients and support the idea that glutamate might play an important role in the pathophysiology of BD." @default.
• W1906130536 created "2016-06-24" @default.
• W1906130536 creator A5012165160 @default.
• W1906130536 creator A5018227298 @default.
• W1906130536 creator A5024208397 @default.
• W1906130536 creator A5035147009 @default.
• W1906130536 creator A5041437469 @default.
• W1906130536 creator A5090658899 @default.
• W1906130536 date "2012-07-26" @default.
• W1906130536 modified "2023-10-09" @default.
• W1906130536 title "Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis" @default.
• W1906130536 cites W1579518684 @default.
• W1906130536 cites W18078213 @default.
• W1906130536 cites W1965143003 @default.
• W1906130536 cites W1971877182 @default.
• W1906130536 cites W1973675690 @default.
• W1906130536 cites W1976870407 @default.
• W1906130536 cites W1978265841 @default.
• W1906130536 cites W1978972146 @default.
• W1906130536 cites W1979449693 @default.
• W1906130536 cites W1980049394 @default.
• W1906130536 cites W1981102082 @default.
• W1906130536 cites W1981253098 @default.
• W1906130536 cites W1981957208 @default.
• W1906130536 cites W1982704116 @default.
• W1906130536 cites W1984190403 @default.
• W1906130536 cites W1986070673 @default.
• W1906130536 cites W1986511484 @default.
• W1906130536 cites W1987450550 @default.
• W1906130536 cites W1989598267 @default.
• W1906130536 cites W1990212220 @default.
• W1906130536 cites W1990348029 @default.
• W1906130536 cites W1991262780 @default.
• W1906130536 cites W1991512531 @default.
• W1906130536 cites W1995167412 @default.
• W1906130536 cites W1997667538 @default.
• W1906130536 cites W1999262903 @default.
• W1906130536 cites W2005614483 @default.
• W1906130536 cites W2005689612 @default.
• W1906130536 cites W2007124673 @default.
• W1906130536 cites W2014331935 @default.
• W1906130536 cites W2014858274 @default.
• W1906130536 cites W2017502608 @default.
• W1906130536 cites W2017803035 @default.
• W1906130536 cites W2022138195 @default.
• W1906130536 cites W2022355264 @default.
• W1906130536 cites W2023630108 @default.
• W1906130536 cites W2024486446 @default.
• W1906130536 cites W2030251229 @default.
• W1906130536 cites W2032791743 @default.
• W1906130536 cites W2033975383 @default.
• W1906130536 cites W2034894224 @default.
• W1906130536 cites W2040957803 @default.
• W1906130536 cites W2048490730 @default.
• W1906130536 cites W2050716480 @default.
• W1906130536 cites W2053914079 @default.
• W1906130536 cites W2055740037 @default.
• W1906130536 cites W2059051998 @default.
• W1906130536 cites W2059129138 @default.
• W1906130536 cites W2061332926 @default.
• W1906130536 cites W2063527418 @default.
• W1906130536 cites W2069436744 @default.
• W1906130536 cites W2069551551 @default.
• W1906130536 cites W2072191054 @default.
• W1906130536 cites W2073699834 @default.
• W1906130536 cites W2074907255 @default.
• W1906130536 cites W2084689734 @default.
• W1906130536 cites W2100556608 @default.
• W1906130536 cites W2102123970 @default.
• W1906130536 cites W2108489849 @default.
• W1906130536 cites W2110767234 @default.
• W1906130536 cites W2117217305 @default.
• W1906130536 cites W2131671310 @default.
• W1906130536 cites W2131942594 @default.
• W1906130536 cites W2133963646 @default.
• W1906130536 cites W2145141773 @default.
• W1906130536 cites W2157143899 @default.
• W1906130536 cites W2159433551 @default.
• W1906130536 cites W2160797407 @default.
• W1906130536 cites W31782020 @default.
• W1906130536 doi "https://doi.org/10.1111/j.1399-5618.2012.01033.x" @default.
• W1906130536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22834460" @default.
• W1906130536 hasPublicationYear "2012" @default.
• W1906130536 type Work @default.
• W1906130536 sameAs 1906130536 @default.
• W1906130536 citedByCount "179" @default.
• W1906130536 countsByYear W19061305362013 @default.
• W1906130536 countsByYear W19061305362014 @default.
• W1906130536 countsByYear W19061305362015 @default.
• W1906130536 countsByYear W19061305362016 @default.
• W1906130536 countsByYear W19061305362017 @default.
• W1906130536 countsByYear W19061305362018 @default.
• W1906130536 countsByYear W19061305362019 @default.
• W1906130536 countsByYear W19061305362020 @default.
• W1906130536 countsByYear W19061305362021 @default.
• W1906130536 countsByYear W19061305362022 @default.
• W1906130536 countsByYear W19061305362023 @default.
• W1906130536 crossrefType "journal-article" @default.

• next