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- W1906144610 abstract "We analyzed lipids extracted from human hepatoma HepG2 cells using a high performance liquid chromatograph equipped with a reversed phase column and found a compound with a mass spectrum showing certain diagnostic ion framgents of 1-methoxy-5-polyprenyl-phenol, a known intermediate of ubiquinone biosynthesis. Universally radiolabeled [14C] -p-hydroxybenzoate, a precursor of ubiquinone, was incorporated into the compound on incubation with the cells, suggesting that the compound is a precursor of ubiquinone. The presence of the compound in the microsomal fraction of HepG2 cells was not due to contamination by the mitochondrial fraction because the activity of succinate-cytochrome c reductase in the microsomal fraction was below 1% of that in the mitochondrial fraction, whereas the contents of ubiquinone and the compound in the former were 4.6 and 7.8% of those in the latter, respectively. These results support the hypothesis that ubiquinone biosynthesis might occur in microsomes as well as mitochondria." @default.
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- W1906144610 date "1990-12-01" @default.
- W1906144610 modified "2023-09-23" @default.
- W1906144610 title "An Intermediate of Ubiquinone Biosynthesis Exists in the Microsomal Fraction of HepG2 Cells1" @default.
- W1906144610 doi "https://doi.org/10.1093/oxfordjournals.jbchem.a123308" @default.
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