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• W1906165386 abstract "RNA molecules uniquely form a complex through specific hairpin loops, called a kissing complex. The kissing complex is widely investigated and used for the construction of RNA nanostructures. Molecular switches have also been created by combining a kissing loop and a ligand-binding aptamer to control the interactions of RNA molecules. In this study, we incorporated two kinds of RNA molecules into a DNA origami structure and used atomic force microscopy to observe their ligand-responsive interactions at the single-molecule level. We used a designed RNA aptamer called GTPswitch, which has a guanosine triphosphate (GTP) responsive domain and can bind to the target RNA hairpin named Aptakiss in the presence of GTP. We observed shape changes of the DNA/RNA strands in the DNA origami, which are induced by the GTPswitch, into two different shapes in the absence and presence of GTP, respectively. We also found that the switching function in the nanospace could be improved by using a cover strand over the kissing loop of the GTPswitch or by deleting one base from this kissing loop. These newly designed ligand-responsive aptamers can be used for the controlled assembly of the various DNA and RNA nanostructures." @default.
• W1906165386 created "2016-06-24" @default.
• W1906165386 creator A5001253974 @default.
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• W1906165386 date "2016-01-01" @default.
• W1906165386 modified "2023-10-14" @default.
• W1906165386 title "Single-molecule observations of RNA–RNA kissing interactions in a DNA nanostructure" @default.
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• W1906165386 doi "https://doi.org/10.1039/c5bm00274e" @default.
• W1906165386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26438892" @default.
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