FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906180472> ?p ?o ?g. }

• W1906180472 endingPage "1339" @default.
• W1906180472 startingPage "1338" @default.
• W1906180472 abstract "To the Editor: Composite tissue allotransplantation (CTA) is emerging as an active area of clinical research for the replacement of nonvital body parts missing usually because of severe injuries. As with other organ transplants, CTA may transmit donor-hosted diseases to their recipients. Conceivably, infectious agents present in the skin or other CTA tissues are able to reach the recipient’s tissues via the bloodstream and to produce systemic infections, favored by the immunosuppressive treatment. The first patient with a facial allograft (FA) developed herpes simplex (HSV) labialis at least on two occasions, both of which were followed by episodes of graft rejection. Since HSV is considered to reside in the lymph nodes wherefrom it spreads to the skin, the donor-skin origin of these infections is however questionable. The patient developed later mollusca contagiosa, benign skin growths due to a poxvirus; these were also most likely not donor-transmitted, since the allograft was healthy at the time of recovery (1Kanitakis J Badet L Petruzzo P et al.Clinicopathological monitoring of the skin and oral mucosa of the first human face allograft. Report on the first eight months.Transplantation. 2006; 82: 1610-1615Crossref PubMed Scopus (91) Google Scholar). The possibility of tumor transmission from CTA exists, although it has not been observed so far. Although this possibility is not very likely, it underscores the necessity of prevention by careful donor screening. The issue of ‘transmission’ of inflammatory skin diseases (ISD) is more subtle, although pathogenetically very interesting. ISD mostly develop from the interaction between resident skin cells with circulating immune-competent cells or antibodies of recipient’s origin. In the case of CTA, the involved cells are heterologous (CTA-including skin-cells are of donor origin and immune cells of recipient’s origin); whether they can/will interact as in an autologous situation in ‘normal’ patients is uncertain. Pomahac et al. (2Pomahac B Pribaz J Eriksson E et al.Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft.Am J Transplant. 2011; 11: 386-393Abstract Full Text Full Text PDF PubMed Scopus (127) Google Scholar) diagnosed the redness of their FA as rosacea ‘transmitted’ by the donor, who had a relevant history. The diagnosis of ‘idiopathic’ rosacea, and especially its transmission from the donor, calls for caution. Pathologically, rosacea manifests with a predominantly neutrophilic infiltrate surrounding/invading the epithelial hair-follicle wall, features that are absent in CTA rejection (and in fig. 4C of ref. 2Pomahac B Pribaz J Eriksson E et al.Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft.Am J Transplant. 2011; 11: 386-393Abstract Full Text Full Text PDF PubMed Scopus (127) Google Scholar). Our FA-recipient developed an almost identical rosacea-like eruption of the FA 2.5 years postgraft (Figure 1). This was most likely due to excessive, long-lasting applications of clobetasol, a high-potency steroid cream known to induce rosacea; the eruption subsided completely upon clobetasol discontinuation and oral cyclin treatment. The patient of Pomahac et al. (2Pomahac B Pribaz J Eriksson E et al.Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft.Am J Transplant. 2011; 11: 386-393Abstract Full Text Full Text PDF PubMed Scopus (127) Google Scholar) also applied clobetasol on the FA, which may have induced steroid-rosacea (favored also by the systemic steroid treatment). The strict limitation of the redness on the FA, both in our patient and that of Pomahac et al. (2Pomahac B Pribaz J Eriksson E et al.Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft.Am J Transplant. 2011; 11: 386-393Abstract Full Text Full Text PDF PubMed Scopus (127) Google Scholar) favors a ‘local’ disease process, not really transmitted to the recipient (the rest of the face was unaffected). Whatever the explanation, the possibility of ISD developing on CTA (especially the face) renders more difficult the diagnosis of rejection, because of overlapping clinicopathological features (3Kanitakis J The challenge of dermatopathological diagnosis of rejection of composite tissue allografts: A review.J Cutan Pathol. 2008; 35: 738-744Crossref PubMed Scopus (63) Google Scholar). On the other hand, apart from dramatically improving the quality of life of patients, CTA will undoubtedly help us better understand the physiology of tissues, both in terms of normal cell origin and renewal (4Kanitakis J Morelon E Petruzzo P Badet L Dubernard JM Self-renewal capacity of human epidermal Langerhans cells: Observations made on a composite tissue allograft.Exp Dermatol. 2011; 20: 145-146Crossref PubMed Scopus (73) Google Scholar) and the cellular origin of diseases. Funding sources: None. The author of this manuscript has no conflicts of interest to disclose as described by the American Journal of Transplantation." @default.
• W1906180472 created "2016-06-24" @default.
• W1906180472 creator A5012298728 @default.
• W1906180472 date "2011-06-01" @default.
• W1906180472 modified "2023-10-01" @default.
• W1906180472 title "Transmission of Rosacea from the Graft in Facial Allotransplantation" @default.
• W1906180472 cites W1511166986 @default.
• W1906180472 cites W1710887510 @default.
• W1906180472 cites W1992496417 @default.
• W1906180472 cites W2018099800 @default.
• W1906180472 doi "https://doi.org/10.1111/j.1600-6143.2011.03507.x" @default.
• W1906180472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21443678" @default.
• W1906180472 hasPublicationYear "2011" @default.
• W1906180472 type Work @default.
• W1906180472 sameAs 1906180472 @default.
• W1906180472 citedByCount "12" @default.
• W1906180472 countsByYear W19061804722013 @default.
• W1906180472 countsByYear W19061804722014 @default.
• W1906180472 countsByYear W19061804722015 @default.
• W1906180472 countsByYear W19061804722018 @default.
• W1906180472 countsByYear W19061804722019 @default.
• W1906180472 countsByYear W19061804722020 @default.
• W1906180472 countsByYear W19061804722021 @default.
• W1906180472 crossrefType "journal-article" @default.
• W1906180472 hasAuthorship W1906180472A5012298728 @default.
• W1906180472 hasBestOaLocation W19061804721 @default.
• W1906180472 hasConcept C119599485 @default.
• W1906180472 hasConcept C127413603 @default.
• W1906180472 hasConcept C141071460 @default.
• W1906180472 hasConcept C142724271 @default.
• W1906180472 hasConcept C16005928 @default.
• W1906180472 hasConcept C203014093 @default.
• W1906180472 hasConcept C2522874641 @default.
• W1906180472 hasConcept C2777561873 @default.
• W1906180472 hasConcept C2780252810 @default.
• W1906180472 hasConcept C2781196997 @default.
• W1906180472 hasConcept C2911091166 @default.
• W1906180472 hasConcept C2911196830 @default.
• W1906180472 hasConcept C71924100 @default.
• W1906180472 hasConcept C761482 @default.
• W1906180472 hasConceptScore W1906180472C119599485 @default.
• W1906180472 hasConceptScore W1906180472C127413603 @default.
• W1906180472 hasConceptScore W1906180472C141071460 @default.
• W1906180472 hasConceptScore W1906180472C142724271 @default.
• W1906180472 hasConceptScore W1906180472C16005928 @default.
• W1906180472 hasConceptScore W1906180472C203014093 @default.
• W1906180472 hasConceptScore W1906180472C2522874641 @default.
• W1906180472 hasConceptScore W1906180472C2777561873 @default.
• W1906180472 hasConceptScore W1906180472C2780252810 @default.
• W1906180472 hasConceptScore W1906180472C2781196997 @default.
• W1906180472 hasConceptScore W1906180472C2911091166 @default.
• W1906180472 hasConceptScore W1906180472C2911196830 @default.
• W1906180472 hasConceptScore W1906180472C71924100 @default.
• W1906180472 hasConceptScore W1906180472C761482 @default.
• W1906180472 hasIssue "6" @default.
• W1906180472 hasLocation W19061804721 @default.
• W1906180472 hasLocation W19061804722 @default.
• W1906180472 hasOpenAccess W1906180472 @default.
• W1906180472 hasPrimaryLocation W19061804721 @default.
• W1906180472 hasRelatedWork W1990544509 @default.
• W1906180472 hasRelatedWork W2028875463 @default.
• W1906180472 hasRelatedWork W2045244606 @default.
• W1906180472 hasRelatedWork W2052063382 @default.
• W1906180472 hasRelatedWork W2070924834 @default.
• W1906180472 hasRelatedWork W2084272222 @default.
• W1906180472 hasRelatedWork W2358939561 @default.
• W1906180472 hasRelatedWork W2426537626 @default.
• W1906180472 hasRelatedWork W2507361224 @default.
• W1906180472 hasRelatedWork W3214058578 @default.
• W1906180472 hasVolume "11" @default.
• W1906180472 isParatext "false" @default.
• W1906180472 isRetracted "false" @default.
• W1906180472 magId "1906180472" @default.
• W1906180472 workType "article" @default.