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• W190627863 abstract "In the normal course of metabolism, oxidant byproducts due to freeradicals formed cause damage to the macromolecules in the cell. Oxidativestress is also caused by various exogenous sources of free radicals thatinclude tobacco smoke, iodizing radiation, pollutants, organic solvents andpesticides. The free radical induced oxidative damage is implicated inseveral degenerative diseases of aging such as atherosclerosis, rheumatoidarthritis, brain dysfunction, cataracts, immunodeficiency and cancer.Living organisms have evolved their own antioxidant defenses againstfree radicals in the form of antioxidant molecules like glutathione and theantioxidant enzymes such as super oxide dismutase, catalase, peroxidaseand other enzymes of detoxification.It is generally recognised that there is an inverse relationship betweendietary intake of antioxidant-rich foods and incidence of human diseases.Several studies indicate that antioxidants present in fruits and vegetablesoffer protective effects against degenerative disease. Therefore, there isgreat deal of interest in the natural antioxidants or the so-callednutraceuticals as dietary supplements for better health.Several phytochemicals with antioxidant properties have beenisolated from plant sources such as flavanoids and polyphenolic compounds.These phytochemicals possess beneficial properties such asanticarcinogenic, antimutagenic, antidiabetic, anti-inflammatory effects inexperimental animals. Many studies have shown specific biochemical actionagainst DNA damage, inhibition of membrane lipid per oxidation and cellulardamage.Recent surge of interest in the area of herbal health supplements andnutraceuticals has resulted in a huge market potential in excess of 1 billionUS $ in USA alone. In ayurveda, the ancient Indian system of medicine avast array of plants with medicinal and health promoting potential are knownand several medicinal compounds have been isolated. Indian biodiversityoffers a rich repertoire of bioactive molecules that are of value in agricultureand medicine. There is a great deal of scientific interest in this area.Decalepis hamiltonii (family: Ascelpediaceae) commonly known asthe swallow root is a shrubby climber (colloquial names: kannada-makaliberu; Tamil-magali kizhangu; Telugu-maredu ghaddalu) with jointed stemand elliptic obviate leaves. It grows wild in the forests of peninsular India. Itsroots are elongated and tuberous with fleshy outer layer and woody innercore and possess strong vanilla-like aromatic odour. Traditionally it has beenconsumed as pickles and the juice made from it is thought to be good forhealth with “cooling properties”. The roots have also been used as asubstitute for Hemidesmus indicus used in ayurvedic preparations. Earlywork on the chemical composition has revealed the presence of amyrins,lupeols, saponins, ketonic substances and 2-hydroxy,4-methoxybenzaldehyde is the flavoring compound present in its volatile fraction.Although the roots of D.hamiltonii are in use since ages with the tribal beliefthat it has positive health benefits, there has been scientific work that hasinvestigated its health promoting potential.The objective of the work was to investigate the health promoting propertiesin the roots and its safety to mammals." @default.
• W190627863 created "2016-06-24" @default.
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• W190627863 date "2005-01-01" @default.
• W190627863 modified "2023-09-26" @default.
• W190627863 title "Mammalian Toxicity Assessment and Nutraceutical Propertiesof the Swallow Root Decalepis Hamiltonii" @default.
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