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- W190628054 abstract "ABSTRACT In experiments with chickens, a suppressive effect of thymus cells could be demonstrated several weeks after cell transfer if the respective antigen was given repeatedly during the period after the transfer. In such experiments the suppressive effect appeared to be antigen specific, and the ME-sensitive antibody (IgG) was as well or even more suppressed than the total antibody titer (practically IgM). The suppressive effect was found to be better maintained over a period of time by repeated application of high doses of antigen than by low doses. By all these criteria, the suppressive effect of thymus cells appeared to be similar to the suppression (“partial tolerance”) that is observed after neonatal application of antigen. The “fingerprinting” of thymus cells by combination of size distribution analysis, preparative cell electrophoresis and density gradient centrifugation revealed 3 major subpopulations of small lymphocytes in the thymus of mice and chickens. The sequential appearance and disappearance of the 3 cell types in the chicken in relation to functional properties suggests 1) that suppressor activity and G.v.H. reactivity are associated with different cell types, and 2) that the suppressor cells may be the predominant cell population in the thymus in early life." @default.
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- W190628054 date "1974-01-01" @default.
- W190628054 modified "2023-10-09" @default.
- W190628054 title "THYMOCYTE SUBPOPULATION WITH SUPPRESSIVE ACTIVITY" @default.
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- W190628054 doi "https://doi.org/10.1016/b978-0-12-637150-5.50034-1" @default.
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