FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906440464> ?p ?o ?g. }

• W1906440464 endingPage "e0132826" @default.
• W1906440464 startingPage "e0132826" @default.
• W1906440464 abstract "The circulating tumor necrosis factor receptors (TNFRs) could predict the long-term renal outcome in diabetes, but the role of circulating TNFRs in other chronic kidney disease has not been reported. Here, we investigated the correlation between circulating TNFRs and renal histologic findings on kidney biopsy in IgA nephropathy (IgAN) and assessed the notion that the circulating TNFRs could predict the clinical outcome. 347 consecutive biopsy-proven IgAN patients between 2006 and 2012 were prospectively enrolled. Concentrations of circulating TNFRs were measured using serum samples stored at the time of biopsy. The primary clinical endpoint was the decline of estimated glomerular filtration rate (eGFR; ≥ 30% decline compared to baseline). Mean eGFR decreased and proteinuria worsened proportionally as circulating TNFR1 and TNFR2 increased (P < 0.001). Tubulointerstitial lesions such as interstitial fibrosis and tubular atrophy were significantly more severe as concentrations of circulating TNFRs increased, regardless of eGFR levels. The risks of reaching the primary endpoint were significantly higher in the highest quartile of TNFRs compared with other quartiles by the Cox proportional hazards model (TNFR1; hazard ratio 7.48, P < 0.001, TNFR2; hazard ratio 2.51, P = 0.021). In stratified analysis according to initial renal function classified by the eGFR levels of 60 mL/min/1.73 m2, TNFR1 and TNFR2 were significant predictors of renal progression in both subgroups. In conclusion, circulating TNFRs reflect the histology and clinical severity of IgAN. Moreover, elevated concentrations of circulating TNFRs at baseline are early biomarkers for subsequent renal progression in IgAN patients." @default.
• W1906440464 created "2016-06-24" @default.
• W1906440464 creator A5022646032 @default.
• W1906440464 creator A5033449275 @default.
• W1906440464 creator A5036891069 @default.
• W1906440464 creator A5044459999 @default.
• W1906440464 creator A5057537444 @default.
• W1906440464 creator A5075976531 @default.
• W1906440464 creator A5078265637 @default.
• W1906440464 creator A5078304487 @default.
• W1906440464 creator A5079910160 @default.
• W1906440464 creator A5083042968 @default.
• W1906440464 creator A5085491969 @default.
• W1906440464 date "2015-07-15" @default.
• W1906440464 modified "2023-09-30" @default.
• W1906440464 title "Circulating Tumor Necrosis Factor α Receptors Predict the Outcomes of Human IgA Nephropathy: A Prospective Cohort Study" @default.
• W1906440464 cites W1485976886 @default.
• W1906440464 cites W1495221405 @default.
• W1906440464 cites W1967992807 @default.
• W1906440464 cites W1968894426 @default.
• W1906440464 cites W1971577009 @default.
• W1906440464 cites W1979445622 @default.
• W1906440464 cites W1981306008 @default.
• W1906440464 cites W1983523234 @default.
• W1906440464 cites W1992754215 @default.
• W1906440464 cites W1999532168 @default.
• W1906440464 cites W2003334292 @default.
• W1906440464 cites W2014395496 @default.
• W1906440464 cites W2020498525 @default.
• W1906440464 cites W2029774820 @default.
• W1906440464 cites W2033180759 @default.
• W1906440464 cites W2052203060 @default.
• W1906440464 cites W2054306338 @default.
• W1906440464 cites W2066224953 @default.
• W1906440464 cites W2069569049 @default.
• W1906440464 cites W2071615161 @default.
• W1906440464 cites W2073742622 @default.
• W1906440464 cites W2074583109 @default.
• W1906440464 cites W2074850565 @default.
• W1906440464 cites W2076825539 @default.
• W1906440464 cites W2078431913 @default.
• W1906440464 cites W2082001761 @default.
• W1906440464 cites W2085701360 @default.
• W1906440464 cites W2086860754 @default.
• W1906440464 cites W2090190493 @default.
• W1906440464 cites W2107250031 @default.
• W1906440464 cites W2111329158 @default.
• W1906440464 cites W2114530399 @default.
• W1906440464 cites W2115034481 @default.
• W1906440464 cites W2117291477 @default.
• W1906440464 cites W2119529895 @default.
• W1906440464 cites W2125558501 @default.
• W1906440464 cites W2126790357 @default.
• W1906440464 cites W2129674624 @default.
• W1906440464 cites W2134020449 @default.
• W1906440464 cites W2134676775 @default.
• W1906440464 cites W2135283049 @default.
• W1906440464 cites W2142918554 @default.
• W1906440464 cites W2146843132 @default.
• W1906440464 cites W2147174712 @default.
• W1906440464 cites W2151053450 @default.
• W1906440464 cites W2160421164 @default.
• W1906440464 cites W2161539727 @default.
• W1906440464 cites W2164326564 @default.
• W1906440464 cites W2164697745 @default.
• W1906440464 cites W2171095755 @default.
• W1906440464 cites W2184044473 @default.
• W1906440464 cites W27385377 @default.
• W1906440464 cites W4241655994 @default.
• W1906440464 cites W4247406457 @default.
• W1906440464 cites W2403486795 @default.
• W1906440464 doi "https://doi.org/10.1371/journal.pone.0132826" @default.
• W1906440464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503615" @default.
• W1906440464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26177311" @default.
• W1906440464 hasPublicationYear "2015" @default.
• W1906440464 type Work @default.
• W1906440464 sameAs 1906440464 @default.
• W1906440464 citedByCount "19" @default.
• W1906440464 countsByYear W19064404642016 @default.
• W1906440464 countsByYear W19064404642017 @default.
• W1906440464 countsByYear W19064404642018 @default.
• W1906440464 countsByYear W19064404642019 @default.
• W1906440464 countsByYear W19064404642020 @default.
• W1906440464 countsByYear W19064404642021 @default.
• W1906440464 countsByYear W19064404642022 @default.
• W1906440464 countsByYear W19064404642023 @default.
• W1906440464 crossrefType "journal-article" @default.
• W1906440464 hasAuthorship W1906440464A5022646032 @default.
• W1906440464 hasAuthorship W1906440464A5033449275 @default.
• W1906440464 hasAuthorship W1906440464A5036891069 @default.
• W1906440464 hasAuthorship W1906440464A5044459999 @default.
• W1906440464 hasAuthorship W1906440464A5057537444 @default.
• W1906440464 hasAuthorship W1906440464A5075976531 @default.
• W1906440464 hasAuthorship W1906440464A5078265637 @default.
• W1906440464 hasAuthorship W1906440464A5078304487 @default.
• W1906440464 hasAuthorship W1906440464A5079910160 @default.
• W1906440464 hasAuthorship W1906440464A5083042968 @default.
• W1906440464 hasAuthorship W1906440464A5085491969 @default.

• next