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- W1906477070 abstract "Abstract Background Psychosocial functioning is associated with vascular endothelial growth factor (VEGF) in various patient populations. This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is associated with tumor VEGF expression, a protein that stimulates angiogenesis and is associated with poor prognosis. Methods Forty‐two newly diagnosed patients completed assessments of psychosocial functioning (ie, depressive symptoms, perceived stress, anxiety, social support) before surgery. Tumor samples were obtained for VEGF analysis and human papillomavirus (HPV)‐typing. Results Poorer psychosocial functioning was associated with greater VEGF expression controlling for disease stage (odds ratio [OR], 4.55; 95% confidence interval [CI], 1.72–12.0; p < .01). When examined by HPV status, the association between psychosocial functioning and VEGF remained significant among patients who were HPV negative (OR, 5.50; 95% CI, 1.68–17.3; p < .01), but not among patients who were HPV positive. Conclusion These findings inform our understanding of the biobehavioral pathways that may contribute to poor outcomes in non‐HPV‐associated HNSCCs. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1113–1119, 2014" @default.
- W1906477070 created "2016-06-24" @default.
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- W1906477070 date "2013-10-26" @default.
- W1906477070 modified "2023-10-17" @default.
- W1906477070 title "Psychosocial functioning and vascular endothelial growth factor in patients with head and neck cancer" @default.
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- W1906477070 doi "https://doi.org/10.1002/hed.23421" @default.
- W1906477070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4099415" @default.
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