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- W1906506093 abstract "Background: The objectives of this prospective hospital based study were to (a) determine the incidence of neural tube defects (NTDs) in Omdurman Maternity Hospital, (b) describe the spectrum of NTDs, (c) report any associated congenital anomalies, (d) assess the role of the sociodemographic risk factors and (e) observe the short term outcome of NTDs. Methods: All babies born in Omdurman Maternity Hospital with clinically detectable NTDs during a one-year-period were enrolled and two consecutive births were taken as controls. All survivors were followed up for three months period. Results: The incidence of NTDs was 3.48/1000; 50% of the cases were myelomeningocele, 38% were anencephaly, 10% encephalocele and one case was iniencephaly. Most of the cases were stillborn or died in the early neonatal period. The male to female ratio was 1:5 and 20% of the cases of NTDs had associated congenital anomalies; 55.5% of the mothers were less than 25 years of age indicating a significant association between NTDs and young maternal age (RR = 2.3, p<0.0001). Most of the parents of the NTDs cases had poor education (RR = 2.4, p<0.001); 54.8% of mothers had previous history of stillbirth (RR = 3.3, p<0.0001); only 30% of mothers had antenatal care (p<0.0001); no mother of the reported cases or control group had used folic acid pre-conception. Conclusion: It is concluded that the incidence of NTDs in Omdurman Maternity hospital is the highest in Africa and this invites a nation-wide registry for all congenital anomalies, improvement of female education and upgrading of maternity care services including active promotion of folic acid supplementation to all women of childbearing age. *Corresponding Author: Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Khartoum P.O. Box 102, Sudan. Email: salahibrah@gmail.com." @default.
- W1906506093 created "2016-06-24" @default.
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- W1906506093 date "2012-02-02" @default.
- W1906506093 modified "2023-09-27" @default.
- W1906506093 title "Neural Tube defects in Omdurman Maternity Hospital, Sudan" @default.
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