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• W1906543170 abstract "Dendritic epidermal T cells (DETCs) are a well-studied population of γδ T cells that play important roles in wound repair. In this study, we characterize a second major population of γδ T cells in the skin that is present in the dermis. In contrast to DETCs, these Vγ5-negative cells are IL-7R(hi)CCR6(hi) retinoic acid-related orphan receptor γt(+) and are precommitted to IL-17 production. Dermal γδ T cells fail to reconstitute following irradiation and bone marrow transplantation unless the mice also receive a transfer of neonatal thymocytes. Real-time intravital imaging of CXCR6(GFP/+) mouse skin reveals dermal γδ T cells migrate at ∼4 μm/min, whereas DETCs are immobile. Like their counterparts in peripheral lymph nodes, dermal γδ T cells rapidly produce IL-17 following exposure to IL-1β plus IL-23. We have characterized a major population of skin γδ T cells and propose that these cells are a key source of IL-17 in the early hours after skin infection." @default.
• W1906543170 created "2016-06-24" @default.
• W1906543170 creator A5020294120 @default.
• W1906543170 creator A5061559047 @default.
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• W1906543170 date "2011-05-02" @default.
• W1906543170 modified "2023-10-11" @default.
• W1906543170 title "Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the Dermis" @default.
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• W1906543170 doi "https://doi.org/10.4049/jimmunol.1100427" @default.
• W1906543170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3098921" @default.
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• W1906543170 hasPublicationYear "2011" @default.
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