Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906564963> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1906564963 startingPage "1520" @default.
- W1906564963 abstract "RationaleOnly 2% of the nucleotides in the human genome code for protein. The overwhelming majority of the human genome is transcribed into non-coding RNA that are divided into house-keeping, short and long non-coding RNA (lncRNA), with the majority being lncRNAs (>200 nucleotides). lncRNAs are classified according to their function and/or their position relative to the transcription of protein-coding RNA and include the antisense, pseudogenes and long intergenic non-coding RNAs (lincRNAs).Asthma is characterised by chronic airflow obstruction, chronic airway inflammation and remodelling. Airway smooth muscle (ASM) cells cultured from the biopsies of patients with asthma are of a hyperproliferative phenotype and release greater amounts of chemokines when compared to non-asthmatic subjects.We have previously found that PVT1 was differentially expressed in asthmatic ASM by TGF-β. We hypothesise that by inhibiting this lincRNA in ASM cells from severe asthmatics, we may reverse the hyperproliferative phenotype.MethodsHuman ASM cells were transfected with a pool of siRNAs designed to target PVT1. Cells were then stimulated with TGF-β. Cellular proliferation and IL-6 release were measured by BrdU incorporation and ELISA, respectively.ResultsInhibiting PVT1 in ASM cells from severe asthmatics reduced both the hyperproliferation and the increased IL-6 release.ConclusionsThis is the first time that the lincRNA, PVT1, has been demonstrated to be fundamental in controlling the hyperproliferative state of ASM cells from severe asthmatics. PVT1 may prove to be a novel target for treatment." @default.
- W1906564963 created "2016-06-24" @default.
- W1906564963 creator A5023601569 @default.
- W1906564963 creator A5024617971 @default.
- W1906564963 creator A5036414874 @default.
- W1906564963 creator A5069286462 @default.
- W1906564963 date "2013-09-01" @default.
- W1906564963 modified "2023-09-27" @default.
- W1906564963 title "The long intergenic non-coding RNA, PVT1, regulates the TGF-β-induced proliferative response in airway smooth muscle cells from severe asthmatics" @default.
- W1906564963 hasPublicationYear "2013" @default.
- W1906564963 type Work @default.
- W1906564963 sameAs 1906564963 @default.
- W1906564963 citedByCount "0" @default.
- W1906564963 crossrefType "journal-article" @default.
- W1906564963 hasAuthorship W1906564963A5023601569 @default.
- W1906564963 hasAuthorship W1906564963A5024617971 @default.
- W1906564963 hasAuthorship W1906564963A5036414874 @default.
- W1906564963 hasAuthorship W1906564963A5069286462 @default.
- W1906564963 hasConcept C104317684 @default.
- W1906564963 hasConcept C127716648 @default.
- W1906564963 hasConcept C138885662 @default.
- W1906564963 hasConcept C179926584 @default.
- W1906564963 hasConcept C203014093 @default.
- W1906564963 hasConcept C2777394393 @default.
- W1906564963 hasConcept C41895202 @default.
- W1906564963 hasConcept C502942594 @default.
- W1906564963 hasConcept C54355233 @default.
- W1906564963 hasConcept C62203573 @default.
- W1906564963 hasConcept C67705224 @default.
- W1906564963 hasConcept C71924100 @default.
- W1906564963 hasConcept C86803240 @default.
- W1906564963 hasConcept C95444343 @default.
- W1906564963 hasConceptScore W1906564963C104317684 @default.
- W1906564963 hasConceptScore W1906564963C127716648 @default.
- W1906564963 hasConceptScore W1906564963C138885662 @default.
- W1906564963 hasConceptScore W1906564963C179926584 @default.
- W1906564963 hasConceptScore W1906564963C203014093 @default.
- W1906564963 hasConceptScore W1906564963C2777394393 @default.
- W1906564963 hasConceptScore W1906564963C41895202 @default.
- W1906564963 hasConceptScore W1906564963C502942594 @default.
- W1906564963 hasConceptScore W1906564963C54355233 @default.
- W1906564963 hasConceptScore W1906564963C62203573 @default.
- W1906564963 hasConceptScore W1906564963C67705224 @default.
- W1906564963 hasConceptScore W1906564963C71924100 @default.
- W1906564963 hasConceptScore W1906564963C86803240 @default.
- W1906564963 hasConceptScore W1906564963C95444343 @default.
- W1906564963 hasLocation W19065649631 @default.
- W1906564963 hasOpenAccess W1906564963 @default.
- W1906564963 hasPrimaryLocation W19065649631 @default.
- W1906564963 hasRelatedWork W101441832 @default.
- W1906564963 hasRelatedWork W1779809968 @default.
- W1906564963 hasRelatedWork W1917862596 @default.
- W1906564963 hasRelatedWork W1999716006 @default.
- W1906564963 hasRelatedWork W2005503891 @default.
- W1906564963 hasRelatedWork W2016060866 @default.
- W1906564963 hasRelatedWork W2024301198 @default.
- W1906564963 hasRelatedWork W2084825374 @default.
- W1906564963 hasRelatedWork W2164207455 @default.
- W1906564963 hasRelatedWork W2266377261 @default.
- W1906564963 hasRelatedWork W2463475492 @default.
- W1906564963 hasRelatedWork W2505915600 @default.
- W1906564963 hasRelatedWork W2548313185 @default.
- W1906564963 hasRelatedWork W2802816247 @default.
- W1906564963 hasRelatedWork W2806135222 @default.
- W1906564963 hasRelatedWork W2809335665 @default.
- W1906564963 hasRelatedWork W2936286167 @default.
- W1906564963 hasRelatedWork W2942806236 @default.
- W1906564963 hasRelatedWork W2996413842 @default.
- W1906564963 hasRelatedWork W3007883175 @default.
- W1906564963 hasVolume "42" @default.
- W1906564963 isParatext "false" @default.
- W1906564963 isRetracted "false" @default.
- W1906564963 magId "1906564963" @default.
- W1906564963 workType "article" @default.