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- W1906573571 abstract "Juvenile rheumatoid arthritis (JRA) is a multifactorial lymphocyte-mediated autoimmune disease in children and adolescents, which causes chronic inflammation of joints and may also affect other organ systems. Recent reports have shown that an imbalance of pro- (interferon-γ, interleukin-17) and anti-inflammatory cytokines (interleukin-10) is responsible for the synovial inflammation in oligoarticular (< 5 joints) and polyarticular (≥ 5 joints) cases. 1 Lin Y.T. Wang C.T. Gershwin M.E. Chiang B.L. The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. Autoimmun Rev. 2011; 10: 482-489 Crossref PubMed Scopus (126) Google Scholar In contrast, systemic JRA is caused by aberrant activation of phagocytes, leading not only to joint effects but also to fevers and various other mild to severe organ system manifestations such as lymphadenopathy or hepatosplenomegaly. 1 Lin Y.T. Wang C.T. Gershwin M.E. Chiang B.L. The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. Autoimmun Rev. 2011; 10: 482-489 Crossref PubMed Scopus (126) Google Scholar The hand is among the major orthopedic areas involved in this potentially debilitating condition. Early recognition of clinical symptoms and prompt diagnostics are crucial to avoid long-term disability. This report will focus on the current evidence and recent literature on this topic." @default.
- W1906573571 created "2016-06-24" @default.
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- W1906573571 date "2015-11-01" @default.
- W1906573571 modified "2023-09-26" @default.
- W1906573571 title "The Hand and Wrist in Juvenile Rheumatoid Arthritis" @default.
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- W1906573571 doi "https://doi.org/10.1016/j.jhsa.2015.06.111" @default.
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