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• W1906651736 abstract "ABSTRACT An a-D-galactoside-specific lectin from Bandeiraea sim-plicifolia (BSLI) showed differential binding to cortical cells of the wool follicle bulb. The lectin bound to cells on one side only of the bulb and was completely blocked by a-D-galactose. The region of lectin binding extended from presumptive cortical cells at the base of the bulb to cortical cells at the top of the bulb, disappearing as cortical cells entered the fibre cortex. An orthocortexspecific monoclonal antibody was used to show that cortical cells recognised by the lectin lie directly below the fibre orthocortex and presumably give rise to the orthocortex. The results suggest that two distinct populations of presumptive cortical cells are present only two to three cell layers from the base of the bulb in a region where no morphological differences are detectable. The lectin-bound pre-cortical cells appear to give rise to orthocortical cells while cells not bound by lectin presumably give rise to paracortical cells. Electron microscopy showed that the lectin bound to sites on the plasma membrane, probably on the extracellular surface. This suggests that the lectin target may be a membrane glycoprotein or glycolipid. Two polypeptides recognised by BSLI were separated from wool follicle extracts by SDS-gel electrophoresis. These polypeptides migrated at approximately 69 kDa and 17 kDa. However, only the 69 kDa molecule showed the expected loss of binding by BSLI in the presence of a-D-galactose. Further work will be required to determine if this glycoprotein is the bulb cell molecule recognised by BSLI. Dermal papilla cells were also bound by BSLI and may carry the same, or a similar, cell-surface molecule to presumptive orthocortical cells. BSLI appears to be a useful marker for detecting patterns of cell differentiation in the bulb that correlate with patterns of cortical cell type in the wool fibre. The lectin may also be a useful tool for distinguishing cortical cells of different lineage in cell culture. Furthermore, the pattern of BSLI binding seen in small follicle bulbs appears to provide some support for a reaction-diffusion model of follicle differentiation." @default.
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• W1906651736 date "1992-06-01" @default.
• W1906651736 modified "2023-10-12" @default.
• W1906651736 title "Differential lectin binding to presumptive cortical cells of the wool follicle bulb" @default.
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• W1906651736 doi "https://doi.org/10.1242/jcs.102.2.353" @default.
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