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- W19066908 endingPage "476" @default.
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- W19066908 abstract "The cells of the central nervous system, and in particular neurons, are metabolically active cells with a high iron requirement. The mechanism(s) by which iron is trafficked across the blood–brain barrier has yet to be fully elucidated. A great interest in central nervous system iron homeostasis is derived from the increasing incidence of neurodegenerative disorders over the last decade. Advances in clinical imaging and the ability to differentiate iron from other metals utilizing magnetic resonance imaging (MRI) has permitted radiological confirmation of brain iron accumulation in patients presenting with neurodegenerative symptoms. The observation that brain iron content increases with aging and is associated with neuropathology has led to a heightened interest in the role of iron in these conditions. The potential for iron to not only participate in but enhance oxidative stress coupled with the concomitant increased tissue iron burden in Parkinson’s disease, Alzheimer’s disease, and aging has led numerous investigators to study the relationship between iron, oxidative injury, and neurodegeneration. The recent identification of many of the proteins required for systemic cellular iron metabolism within the central nervous system (CNS) and the subsequent characterization of neurodegenerative disorders attributed to mutations in these proteins have even further highlighted the critical role of iron in CNS functioning." @default.
- W19066908 created "2016-06-24" @default.
- W19066908 creator A5020597178 @default.
- W19066908 creator A5036038594 @default.
- W19066908 creator A5041939163 @default.
- W19066908 creator A5070024026 @default.
- W19066908 date "2011-11-24" @default.
- W19066908 modified "2023-09-27" @default.
- W19066908 title "Neuropathology and Iron: Central Nervous System Iron Homeostasis" @default.
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