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- W1906706885 abstract "Elucidating the consequences of genetic differences between humans is essential for understanding phenotypic diversity and personalized medicine. Although variation in RNA levels, transcription factor binding, and chromatin have been explored, little is known about global variation in translation and its genetic determinants. We used ribosome profiling, RNA sequencing, and mass spectrometry to perform an integrated analysis in lymphoblastoid cell lines from a diverse group of individuals. We find significant differences in RNA, translation, and protein levels suggesting diverse mechanisms of personalized gene expression control. Combined analysis of RNA expression and ribosome occupancy improves the identification of individual protein level differences. Finally, we identify genetic differences that specifically modulate ribosome occupancy--many of these differences lie close to start codons and upstream ORFs. Our results reveal a new level of gene expression variation among humans and indicate that genetic variants can cause changes in protein levels through effects on translation." @default.
- W1906706885 created "2016-06-24" @default.
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- W1906706885 date "2015-08-21" @default.
- W1906706885 modified "2023-10-16" @default.
- W1906706885 title "Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans" @default.
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- W1906706885 doi "https://doi.org/10.1101/gr.193342.115" @default.
- W1906706885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4617958" @default.
- W1906706885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26297486" @default.
- W1906706885 hasPublicationYear "2015" @default.
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