Matches in SemOpenAlex for { <https://semopenalex.org/work/W1906849961> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1906849961 endingPage "1649" @default.
- W1906849961 startingPage "1643" @default.
- W1906849961 abstract "Taraxasterol, a pentacyclic triterpene from Taraxacum officinale, is one of the main active constituents of the herb. This study developed and validated a highly selective and sensitive liquid chromatography/tandem mass spectrometry for the determination of taraxasterol in rat plasma over the range of 9.0-5000 ng/mL. Chromatographic separation was achieved on a C18 (4.6 × 50 mm, 5.0 µm) column with methanol-isopropanol-water-formic acid (80:10:10:0.1, v/v/v/v) as mobile phase with an isocratic elution. The flow rate was 0.7 mL/min. After adding cucurbitacin IIa as an internal standard (IS), liquid-liquid extraction was used for sample preparation using ethyl acetate. The atmospheric pressure chemical ionization source was applied and operated in positive ion mode. Selected reaction monitoring mode was used for the quantification of transition ions m/z 409.4 → 137.1 for taraxasterol and m/z 503.4 → 113.1 for IS. The mean recoveries of taraxasterol in rat plasma ranged from 85.3 to 87.2%. The matrix effects for taraxasterol were between 98.5 and 104.0%. Intra- and inter-day precision were both <11.8%, and the accuracy of the method ranged from -7.0 to 12.9%. The method was successfully applied to a pharmacokinetic study of taraxasterol after oral administration of 7.75, 15.5 and 31.0 mg/kg in rats." @default.
- W1906849961 created "2016-06-24" @default.
- W1906849961 creator A5014985440 @default.
- W1906849961 creator A5034735808 @default.
- W1906849961 creator A5037214616 @default.
- W1906849961 creator A5051181240 @default.
- W1906849961 creator A5053204420 @default.
- W1906849961 date "2015-04-14" @default.
- W1906849961 modified "2023-10-06" @default.
- W1906849961 title "Quantification of taraxasterol in rat plasma by LC/MS/MS: application to a pharmacokinetic study" @default.
- W1906849961 cites W1494198086 @default.
- W1906849961 cites W1537700882 @default.
- W1906849961 cites W1968157018 @default.
- W1906849961 cites W1976544102 @default.
- W1906849961 cites W1980194566 @default.
- W1906849961 cites W1990275174 @default.
- W1906849961 cites W1995039600 @default.
- W1906849961 cites W2007573149 @default.
- W1906849961 cites W2022791025 @default.
- W1906849961 cites W2023745781 @default.
- W1906849961 cites W2036572511 @default.
- W1906849961 cites W2052882033 @default.
- W1906849961 cites W2057468801 @default.
- W1906849961 cites W2061621557 @default.
- W1906849961 cites W2081274536 @default.
- W1906849961 cites W2160960762 @default.
- W1906849961 cites W2323015561 @default.
- W1906849961 doi "https://doi.org/10.1002/bmc.3473" @default.
- W1906849961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25873241" @default.
- W1906849961 hasPublicationYear "2015" @default.
- W1906849961 type Work @default.
- W1906849961 sameAs 1906849961 @default.
- W1906849961 citedByCount "5" @default.
- W1906849961 countsByYear W19068499612018 @default.
- W1906849961 countsByYear W19068499612022 @default.
- W1906849961 crossrefType "journal-article" @default.
- W1906849961 hasAuthorship W1906849961A5014985440 @default.
- W1906849961 hasAuthorship W1906849961A5034735808 @default.
- W1906849961 hasAuthorship W1906849961A5037214616 @default.
- W1906849961 hasAuthorship W1906849961A5051181240 @default.
- W1906849961 hasAuthorship W1906849961A5053204420 @default.
- W1906849961 hasConcept C112705442 @default.
- W1906849961 hasConcept C126322002 @default.
- W1906849961 hasConcept C142724271 @default.
- W1906849961 hasConcept C162356407 @default.
- W1906849961 hasConcept C185592680 @default.
- W1906849961 hasConcept C204787440 @default.
- W1906849961 hasConcept C2777379063 @default.
- W1906849961 hasConcept C2780527577 @default.
- W1906849961 hasConcept C31827203 @default.
- W1906849961 hasConcept C43617362 @default.
- W1906849961 hasConcept C4725764 @default.
- W1906849961 hasConcept C64489805 @default.
- W1906849961 hasConcept C71043704 @default.
- W1906849961 hasConcept C71924100 @default.
- W1906849961 hasConcept C73826308 @default.
- W1906849961 hasConceptScore W1906849961C112705442 @default.
- W1906849961 hasConceptScore W1906849961C126322002 @default.
- W1906849961 hasConceptScore W1906849961C142724271 @default.
- W1906849961 hasConceptScore W1906849961C162356407 @default.
- W1906849961 hasConceptScore W1906849961C185592680 @default.
- W1906849961 hasConceptScore W1906849961C204787440 @default.
- W1906849961 hasConceptScore W1906849961C2777379063 @default.
- W1906849961 hasConceptScore W1906849961C2780527577 @default.
- W1906849961 hasConceptScore W1906849961C31827203 @default.
- W1906849961 hasConceptScore W1906849961C43617362 @default.
- W1906849961 hasConceptScore W1906849961C4725764 @default.
- W1906849961 hasConceptScore W1906849961C64489805 @default.
- W1906849961 hasConceptScore W1906849961C71043704 @default.
- W1906849961 hasConceptScore W1906849961C71924100 @default.
- W1906849961 hasConceptScore W1906849961C73826308 @default.
- W1906849961 hasIssue "11" @default.
- W1906849961 hasLocation W19068499611 @default.
- W1906849961 hasLocation W19068499612 @default.
- W1906849961 hasOpenAccess W1906849961 @default.
- W1906849961 hasPrimaryLocation W19068499611 @default.
- W1906849961 hasRelatedWork W1968381290 @default.
- W1906849961 hasRelatedWork W1968441093 @default.
- W1906849961 hasRelatedWork W1985701257 @default.
- W1906849961 hasRelatedWork W2018493658 @default.
- W1906849961 hasRelatedWork W2093402573 @default.
- W1906849961 hasRelatedWork W2120155947 @default.
- W1906849961 hasRelatedWork W2151017812 @default.
- W1906849961 hasRelatedWork W2167863534 @default.
- W1906849961 hasRelatedWork W4251012885 @default.
- W1906849961 hasRelatedWork W4323347615 @default.
- W1906849961 hasVolume "29" @default.
- W1906849961 isParatext "false" @default.
- W1906849961 isRetracted "false" @default.
- W1906849961 magId "1906849961" @default.
- W1906849961 workType "article" @default.