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• W1906991930 abstract "Abstract Aim Supervised consumption of opioid maintenance treatment ( OMT ) is standard in many drug centres reducing drug diversion, but is costly. We aimed to determine whether supervised consumption of OMT improved retention and other measures of drug use. Design Pragmatic randomized controlled trial comparing 3 months of daily supervised consumption of OMT with 1 month or less of daily supervised OMT , then daily unsupervised consumption. Setting Four community drug services in the U nited K ingdom. Participants A total of 293 opioid‐dependent patients entering OMT . Measurements Primary outcome: retention in treatment at 12 weeks. Secondary: retention at 6 months; illicit drug use [ M audsley A ddiction P rofile ( MAP )]; quality of life ( SF ‐12 and MAP ); criminality ( MAP ); and social functioning. Findings No significant between‐group difference was observed for the primary outcome: 69% (100 of 145) supervised and 74% (109 of 148) unsupervised were retained [odds ratio ( OR) = 0.74, 95% confidence interval ( CI) = 0.43–1.27]. Per protocol survival analysis suggested that supervised patients were less well retained (hazard ratio for retention = 0.71, 95% CI = 0.51–1.00). Illicit opioid use reduced in both groups and, while not statistically significant by intention‐to‐treat analysis, favoured unsupervised patients in per protocol analysis (odds of positive opioid screen for supervised versus unsupervised = 2.07, 95% CI = 1.05–4.06). Data on criminal activity also favoured unsupervised patients with 21% supervised patients committing crime versus 9% unsupervised (OR = 3.37, 95% CI = 1.28–8.86). Conclusions There was no evidence of a difference in treatment retention or opioid use rates between patients whose consumption of opioid maintenance treatment was supervised for 3 months daily (except Saturdays) compared with supervision for 1 month. There was some evidence that longer periods of supervised consumption were associated with higher levels of criminality." @default.
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• W1906991930 date "2014-01-19" @default.
• W1906991930 modified "2023-10-07" @default.
• W1906991930 title "Treatment retention, drug use and social functioning outcomes in those receiving 3 months versus 1 month of supervised opioid maintenance treatment. Results from the Super C randomized controlled trial" @default.
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• W1906991930 doi "https://doi.org/10.1111/add.12439" @default.
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