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- W1907031222 abstract "Summary Brazilian purpuric fever (BPF) is a fulminant septicaemic infection of young children, caused by a clonal group of strains of Haemophilus influenzae biogroup aegyptius ( Hae ), an organism previously solely associated with conjunctivitis. Their special capacity to invade from the initial site of conjunctival infection is unexplained. A polymerase chain reaction (PCR)‐amplified subtractive hybridization technique was used to identify genes specific to the BPF clonal group. A copy of bacteriophage HP1 and 46 further chromosomal loci were identified in the BPF but not in the conjunctivitis strain of Hae . Sixteen were characterized further, and one – encoding an analogue of the Legionella pneumophila epithelial cell entry‐enhancing protein EnhC – was investigated in depth. Two genes, bpf001 and bpf002 , unique to the BPF clonal group were identified between homologues of HI1276 and HI1277 in a complex locus close to H. influenzae genetic island 1, recently identified in pathogenic H. influenzae type b. Bpf001 encodes a protein homologous to EnhC and to the previously uncharacterized product of the meningococcal gene NMB0419 . Functional studies of bpf001 proving intractable, NMB0419 was chosen as a surrogate for investigation and shown to modulate bacterial interaction with monolayers of human respiratory epithelial cells, promoting invasion, the first stage (for Hae ) in the pathogenesis of BPF." @default.
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- W1907031222 date "2003-02-01" @default.
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- W1907031222 title "Identification and characterization of genomic loci unique to the Brazilian purpuric fever clonal group of H. influenzae biogroup aegyptius: functionality explored using meningococcal homology" @default.
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- W1907031222 doi "https://doi.org/10.1046/j.1365-2958.2003.03359.x" @default.
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