Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907036698> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1907036698 endingPage "93" @default.
- W1907036698 startingPage "2789" @default.
- W1907036698 abstract "The glutathione S-transferases (alpha, mu, and pi), a family of Phase II detoxication enzymes, play a critical role in protecting the colon mucosa by catalyzing the conjugation of dietary carcinogens with glutathione. We investigated the efficacy of using the glutathione S-transferase (GST) activity of blood lymphocytes and GST-mu expression as biomarkers of risk for colorectal cancer. GST activity was measured in the blood lymphocytes of control individuals (n = 67) and in the blood lymphocytes (n = 60) and colon tissue (n = 34) of individuals at increased risk for colon cancer. Total GST activity was determined spectrophotometrically with the use of 1-chloro-2,4-dinitrobenzene as a substrate. The ability to express the um subclass of GST was determined with the use of an ELISA. Although interindividual variability in the GST activity of blood lymphocytes was greater than 8-fold (range, 16.7-146.8 nmol/min/mg), the GST activity of blood lymphocytes and colon tissue within an individual was constant over time and was unrelated to sex, age, or race. The GST activity of blood lymphocytes from high-risk individuals was significantly lower than that of blood lymphocytes from control individuals (P < or = 0.004). No association was observed between the frequency of GST-mu phenotype and risk for colorectal cancer. Blood lymphocytes from high-risk individuals unable to express GST-mu had lower levels of GST activity than did those from control subjects with the GST-mu null phenotype; however, this difference was significant in male subjects only (P < or = 0.006). Analysis of paired samples of blood lymphocytes and colon tissue indicated a strong correlation between the GST activity of the two tissue types (Spearman's rank correlation, r = 0.87; P < or = 0.0001). The GST activity of blood lymphocytes may be used to identify high-risk individuals with decreased protection from this Phase II detoxication enzyme who may benefit from clinical trials evaluating GST modulators as chemopreventive agents for colorectal cancer. The GST activity of blood lymphocytes may also be used in colorectal cancer chemoprevention trials to monitor the responsiveness of colon tissue to regimens that modify Phase II detoxication enzymes." @default.
- W1907036698 created "2016-06-24" @default.
- W1907036698 creator A5000635922 @default.
- W1907036698 creator A5002825676 @default.
- W1907036698 creator A5006265692 @default.
- W1907036698 creator A5008909789 @default.
- W1907036698 creator A5009692912 @default.
- W1907036698 creator A5022569332 @default.
- W1907036698 creator A5022901686 @default.
- W1907036698 creator A5029805813 @default.
- W1907036698 creator A5045885319 @default.
- W1907036698 creator A5048609605 @default.
- W1907036698 creator A5052103853 @default.
- W1907036698 date "1995-07-01" @default.
- W1907036698 modified "2023-09-26" @default.
- W1907036698 title "Glutathione S-transferase activity and glutathione S-transferase mu expression in subjects with risk for colorectal cancer." @default.
- W1907036698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7796404" @default.
- W1907036698 hasPublicationYear "1995" @default.
- W1907036698 type Work @default.
- W1907036698 sameAs 1907036698 @default.
- W1907036698 citedByCount "34" @default.
- W1907036698 countsByYear W19070366982012 @default.
- W1907036698 countsByYear W19070366982013 @default.
- W1907036698 countsByYear W19070366982015 @default.
- W1907036698 countsByYear W19070366982017 @default.
- W1907036698 countsByYear W19070366982018 @default.
- W1907036698 crossrefType "journal-article" @default.
- W1907036698 hasAuthorship W1907036698A5000635922 @default.
- W1907036698 hasAuthorship W1907036698A5002825676 @default.
- W1907036698 hasAuthorship W1907036698A5006265692 @default.
- W1907036698 hasAuthorship W1907036698A5008909789 @default.
- W1907036698 hasAuthorship W1907036698A5009692912 @default.
- W1907036698 hasAuthorship W1907036698A5022569332 @default.
- W1907036698 hasAuthorship W1907036698A5022901686 @default.
- W1907036698 hasAuthorship W1907036698A5029805813 @default.
- W1907036698 hasAuthorship W1907036698A5045885319 @default.
- W1907036698 hasAuthorship W1907036698A5048609605 @default.
- W1907036698 hasAuthorship W1907036698A5052103853 @default.
- W1907036698 hasConcept C114246631 @default.
- W1907036698 hasConcept C121608353 @default.
- W1907036698 hasConcept C126322002 @default.
- W1907036698 hasConcept C134018914 @default.
- W1907036698 hasConcept C1621761 @default.
- W1907036698 hasConcept C181199279 @default.
- W1907036698 hasConcept C203014093 @default.
- W1907036698 hasConcept C2776907368 @default.
- W1907036698 hasConcept C526805850 @default.
- W1907036698 hasConcept C538909803 @default.
- W1907036698 hasConcept C55493867 @default.
- W1907036698 hasConcept C71924100 @default.
- W1907036698 hasConcept C86803240 @default.
- W1907036698 hasConceptScore W1907036698C114246631 @default.
- W1907036698 hasConceptScore W1907036698C121608353 @default.
- W1907036698 hasConceptScore W1907036698C126322002 @default.
- W1907036698 hasConceptScore W1907036698C134018914 @default.
- W1907036698 hasConceptScore W1907036698C1621761 @default.
- W1907036698 hasConceptScore W1907036698C181199279 @default.
- W1907036698 hasConceptScore W1907036698C203014093 @default.
- W1907036698 hasConceptScore W1907036698C2776907368 @default.
- W1907036698 hasConceptScore W1907036698C526805850 @default.
- W1907036698 hasConceptScore W1907036698C538909803 @default.
- W1907036698 hasConceptScore W1907036698C55493867 @default.
- W1907036698 hasConceptScore W1907036698C71924100 @default.
- W1907036698 hasConceptScore W1907036698C86803240 @default.
- W1907036698 hasIssue "13" @default.
- W1907036698 hasLocation W19070366981 @default.
- W1907036698 hasOpenAccess W1907036698 @default.
- W1907036698 hasPrimaryLocation W19070366981 @default.
- W1907036698 hasRelatedWork W142053706 @default.
- W1907036698 hasRelatedWork W18016559 @default.
- W1907036698 hasRelatedWork W1907036698 @default.
- W1907036698 hasRelatedWork W1998787023 @default.
- W1907036698 hasRelatedWork W2036182717 @default.
- W1907036698 hasRelatedWork W2095481614 @default.
- W1907036698 hasRelatedWork W2163288640 @default.
- W1907036698 hasRelatedWork W2283644652 @default.
- W1907036698 hasRelatedWork W294744944 @default.
- W1907036698 hasRelatedWork W3030250771 @default.
- W1907036698 hasVolume "55" @default.
- W1907036698 isParatext "false" @default.
- W1907036698 isRetracted "false" @default.
- W1907036698 magId "1907036698" @default.
- W1907036698 workType "article" @default.