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• W190712062 abstract "Research Article15 October 1996free access G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. J. van Deursen J. van Deursen Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author J. Boer J. Boer Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author L. Kasper L. Kasper Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author G. Grosveld G. Grosveld Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author J. van Deursen J. van Deursen Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author J. Boer J. Boer Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author L. Kasper L. Kasper Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author G. Grosveld G. Grosveld Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Search for more papers by this author Author Information J. Deursen1, J. Boer1, L. Kasper1 and G. Grosveld1 1Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA. The EMBO Journal (1996)15:5574-5583https://doi.org/10.1002/j.1460-2075.1996.tb00942.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The vertebrate nucleopore complex (NPC) is a 125 MDa multiprotein assembly that mediates nucleocytoplasmic transport. One of its components, CAN/Nup214, is an FXFG repeat-containing protein known to be involved in myeloid leukemia in humans. We have devised a powerful genetic approach, using maternally derived protein in murine null embryos, to show that CAN/ Nup214 is essential for NPC function in vivo. We demonstrate that CAN−/− mouse embryonic stem (ES) cells are not viable and that CAN−/− embryos die in utero between 4.0 and 4.5 days postcoitum, following the depletion of their CAN from maternal sources. In 3.5-day-old mutant embryos, cultured in vitro, progressive depletion of CAN leads to cell cycle arrest in G2 phase, and eventually to blastocoel collapse, impaired NLS-mediated protein uptake and nuclear accumulation of polyadenylated RNA. Remarkably, these defective CAN-depleted embryos do not display any gross morphological abnormalities in their nuclear envelopes or NPCs. Our data suggest that CAN is critical to cell cycle progression and required for both nuclear protein import and mRNA export. Previous ArticleNext Article Volume 15Issue 201 October 1996In this issue RelatedDetailsLoading ..." @default.
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• W190712062 title "G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214." @default.
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• W190712062 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00942.x" @default.
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