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- W1907342860 endingPage "9668" @default.
- W1907342860 startingPage "9657" @default.
- W1907342860 abstract "// Urszula L. McClurg 1 and Craig N. Robson 1 1 Solid Tumour Target Discovery Laboratory, Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK Correspondence to: Craig N. Robson, email: // Keywords : deubiquitination, DUBs, cancer, epigenetics, chromatin, androgen receptor, histones Received : March 09, 2015 Accepted : April 08, 2015 Published : April 23, 2015 Abstract Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics. Epigenetic processes are regulated by post-translational modifications including ubiquitination which can directly affect either histones or transcription factors or may target their co-factors and interacting partners exerting an indirect effect. Deubiquitination of these target proteins is equally important and alterations in this pathway can also lead to cancer development, progression and metastasis. Only the correct, unaltered balance between ubiquitination and deubiquitination ensures healthy cellular homeostasis. In this review we focus on the role of deubiquitinating (DUB) enzymes in various aspects of epigenetics including the regulation of transcription factors, histone modifications, DNA damage repair pathways and cell cycle regulation. We discuss the impact of those processes on tumourigenesis and potential therapeutic applications of DUBs for cancer treatment." @default.
- W1907342860 created "2016-06-24" @default.
- W1907342860 creator A5062478414 @default.
- W1907342860 creator A5084962664 @default.
- W1907342860 date "2015-04-23" @default.
- W1907342860 modified "2023-10-15" @default.
- W1907342860 title "Deubiquitinating enzymes as oncotargets" @default.
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