FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907387653> ?p ?o ?g. }

• W1907387653 endingPage "597" @default.
• W1907387653 startingPage "591" @default.
• W1907387653 abstract "With the aim of finding new bioactive compounds, a series of phenoxyacetophenone derivatives 2 were designed and synthesized as oxygen analogs of dihydrochalcones. Also, phenoxyacetophenones were converted to (Z)-oxime derivatives 3 and their geometry were characterized by ¹H-NMR spectroscopy. The in vitro antifungal activity of compounds 2 and 3 was evaluated against Candida albicans, Candida glabrata, Saccharomyces cerevisiae, and Aspergillus niger using micro-dilution method. In general, oxime derivative 3d containing 4-fluorophenoxy moiety showed comparable or more potent antifungal activity (MICs = 15.63-31.25 μg/mL) with respect to the reference drug fluconazole against all tested yeasts. In addition, the antileishmanial activity of title compounds was determined against pormastigote form of Leishmania major. All compounds showed mild growth inhibitory activity against promastigotes. The most active compound was unsubstituted phenoxyacetophenone 2a (IC₅₀ = 80 μg/mL). To anticipate the potential use as drugs, the target compounds were evaluated in their drug-like properties. The in silico values of molecular descriptors for bioactive compounds 2a and 3d revealed that these compounds are within the range set by Lipinski's 'Rule of 5' and show no violation of these rules. Moreover, bioactive compounds 2a and 3d are supposed to be non-mutagenic and non-tumorigenic, with no irritating or reproductive effects." @default.
• W1907387653 created "2016-06-24" @default.
• W1907387653 creator A5010172433 @default.
• W1907387653 creator A5021475434 @default.
• W1907387653 creator A5039784428 @default.
• W1907387653 creator A5041924332 @default.
• W1907387653 creator A5042217319 @default.
• W1907387653 creator A5042267273 @default.
• W1907387653 creator A5047586808 @default.
• W1907387653 creator A5062436088 @default.
• W1907387653 date "2012-07-13" @default.
• W1907387653 modified "2023-09-25" @default.
• W1907387653 title "Replacement of the Methylene of Dihydrochalcones with Oxygen: Synthesis and Biological Evaluation of 2-Phenoxyacetophenones" @default.
• W1907387653 cites W1969175601 @default.
• W1907387653 cites W1969816714 @default.
• W1907387653 cites W1970502935 @default.
• W1907387653 cites W1981737096 @default.
• W1907387653 cites W1981798978 @default.
• W1907387653 cites W1995789505 @default.
• W1907387653 cites W1998304447 @default.
• W1907387653 cites W2014404311 @default.
• W1907387653 cites W2022261420 @default.
• W1907387653 cites W2042809651 @default.
• W1907387653 cites W2042867615 @default.
• W1907387653 cites W2046849077 @default.
• W1907387653 cites W2069616038 @default.
• W1907387653 cites W2082998776 @default.
• W1907387653 cites W2135191368 @default.
• W1907387653 cites W2173465901 @default.
• W1907387653 cites W2949409615 @default.
• W1907387653 cites W2951224022 @default.
• W1907387653 cites W2952775595 @default.
• W1907387653 doi "https://doi.org/10.1111/j.1747-0285.2012.01432.x" @default.
• W1907387653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22712717" @default.
• W1907387653 hasPublicationYear "2012" @default.
• W1907387653 type Work @default.
• W1907387653 sameAs 1907387653 @default.
• W1907387653 citedByCount "5" @default.
• W1907387653 countsByYear W19073876532014 @default.
• W1907387653 countsByYear W19073876532016 @default.
• W1907387653 countsByYear W19073876532017 @default.
• W1907387653 countsByYear W19073876532019 @default.
• W1907387653 crossrefType "journal-article" @default.
• W1907387653 hasAuthorship W1907387653A5010172433 @default.
• W1907387653 hasAuthorship W1907387653A5021475434 @default.
• W1907387653 hasAuthorship W1907387653A5039784428 @default.
• W1907387653 hasAuthorship W1907387653A5041924332 @default.
• W1907387653 hasAuthorship W1907387653A5042217319 @default.
• W1907387653 hasAuthorship W1907387653A5042267273 @default.
• W1907387653 hasAuthorship W1907387653A5047586808 @default.
• W1907387653 hasAuthorship W1907387653A5062436088 @default.
• W1907387653 hasBestOaLocation W19073876531 @default.
• W1907387653 hasConcept C104317684 @default.
• W1907387653 hasConcept C178790620 @default.
• W1907387653 hasConcept C185592680 @default.
• W1907387653 hasConcept C2775905019 @default.
• W1907387653 hasConcept C2775960407 @default.
• W1907387653 hasConcept C2776568683 @default.
• W1907387653 hasConcept C2779548794 @default.
• W1907387653 hasConcept C2779648554 @default.
• W1907387653 hasConcept C2780651595 @default.
• W1907387653 hasConcept C2780670043 @default.
• W1907387653 hasConcept C2780917455 @default.
• W1907387653 hasConcept C41847442 @default.
• W1907387653 hasConcept C55493867 @default.
• W1907387653 hasConcept C71240020 @default.
• W1907387653 hasConcept C86803240 @default.
• W1907387653 hasConcept C89423630 @default.
• W1907387653 hasConceptScore W1907387653C104317684 @default.
• W1907387653 hasConceptScore W1907387653C178790620 @default.
• W1907387653 hasConceptScore W1907387653C185592680 @default.
• W1907387653 hasConceptScore W1907387653C2775905019 @default.
• W1907387653 hasConceptScore W1907387653C2775960407 @default.
• W1907387653 hasConceptScore W1907387653C2776568683 @default.
• W1907387653 hasConceptScore W1907387653C2779548794 @default.
• W1907387653 hasConceptScore W1907387653C2779648554 @default.
• W1907387653 hasConceptScore W1907387653C2780651595 @default.
• W1907387653 hasConceptScore W1907387653C2780670043 @default.
• W1907387653 hasConceptScore W1907387653C2780917455 @default.
• W1907387653 hasConceptScore W1907387653C41847442 @default.
• W1907387653 hasConceptScore W1907387653C55493867 @default.
• W1907387653 hasConceptScore W1907387653C71240020 @default.
• W1907387653 hasConceptScore W1907387653C86803240 @default.
• W1907387653 hasConceptScore W1907387653C89423630 @default.
• W1907387653 hasIssue "4" @default.
• W1907387653 hasLocation W19073876531 @default.
• W1907387653 hasLocation W19073876532 @default.
• W1907387653 hasOpenAccess W1907387653 @default.
• W1907387653 hasPrimaryLocation W19073876531 @default.
• W1907387653 hasRelatedWork W1982792348 @default.
• W1907387653 hasRelatedWork W2066569239 @default.
• W1907387653 hasRelatedWork W2078880395 @default.
• W1907387653 hasRelatedWork W2144461882 @default.
• W1907387653 hasRelatedWork W2146122122 @default.
• W1907387653 hasRelatedWork W2570112809 @default.
• W1907387653 hasRelatedWork W2749864230 @default.
• W1907387653 hasRelatedWork W2765279632 @default.
• W1907387653 hasRelatedWork W3194797689 @default.

• next