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• W1907565590 abstract "BACKGROUND: Nucleic acid testing (NAT)‐based methods for the detection and quantification of human immunodeficiency virus Type 1 (HIV‐1) RNA are used to increase transfusion safety and to diagnose and manage HIV‐1‐infected patients. We describe a novel HIV‐1 recombinant form associated with lack of reactivity or substantial underestimation of viral load by commercial NAT assays. STUDY DESIGN AND METHODS: We observed a repeat blood donor seroconverting to anti‐HIV in whom HIV RNA was initially undetectable with routine NAT was observed. During donor follow‐up, HIV RNA became detectable, but the viral load was 2 to 3 log lower than measured with other NATs targeting different genome regions. Genome sequencing revealed a novel B/F recombinant with mutations affecting primers and probe annealing accounting for the poor performance of routine NAT. A total of 553 HIV‐1‐infected patients attending the hospital clinic were subsequently tested prospectively using the routine assay and an in‐house assay specifically designed to detect the B/F strains. RESULTS: The routine assay substantially underestimated viremia (1‐5 log) in 19 cases (3.5%), 11 (58%) of which were infected with the same B/F strain observed in the index donor samples. Two other non‐B circulating recombinant forms of HIV‐1 (A/G, B/G subtypes) were identified as poorly detected. Newly introduced NATs targeting two HIV‐1 regions improved assay performance. CONCLUSION: HIV‐1 increasing heterogeneity affects the efficiency of NATs and consequently the safety of the blood supply as well as diagnosis and patient management." @default.
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• W1907565590 date "2010-11-18" @default.
• W1907565590 modified "2023-10-16" @default.
• W1907565590 title "A cluster of human immunodeficiency virus Type 1 recombinant form escaping detection by commercial genomic amplification assays" @default.
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• W1907565590 doi "https://doi.org/10.1111/j.1537-2995.2010.02942.x" @default.
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