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- W1907569406 abstract "We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B cell commitment, whereas CpG methylation changed extensively during B cell maturation, showing an accumulative pattern and affecting around 30% of all measured CpG sites. Early differentiation stages mainly displayed enhancer demethylation, which was associated with upregulation of key B cell transcription factors and affected multiple genes involved in B cell biology. Late differentiation stages, in contrast, showed extensive demethylation of heterochromatin and methylation gain at Polycomb-repressed areas, and genes with apparent functional impact in B cells were not affected. This signature, which has previously been linked to aging and cancer, was particularly widespread in mature cells with an extended lifespan. Comparing B cell neoplasms with their normal counterparts, we determined that they frequently acquire methylation changes in regions already undergoing dynamic methylation during normal B cell differentiation." @default.
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- W1907569406 date "2015-06-08" @default.
- W1907569406 modified "2023-10-14" @default.
- W1907569406 title "Whole-genome fingerprint of the DNA methylome during human B cell differentiation" @default.
- W1907569406 cites W1611185316 @default.
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- W1907569406 cites W1986560938 @default.
- W1907569406 cites W1987557775 @default.
- W1907569406 cites W1990958459 @default.
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- W1907569406 cites W2004729058 @default.
- W1907569406 cites W2008618369 @default.
- W1907569406 cites W2011730338 @default.
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- W1907569406 cites W2025648894 @default.
- W1907569406 cites W2029742174 @default.
- W1907569406 cites W2032700279 @default.
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- W1907569406 cites W2087485599 @default.
- W1907569406 cites W2097626332 @default.
- W1907569406 cites W2101870168 @default.
- W1907569406 cites W2102663142 @default.
- W1907569406 cites W2105031411 @default.
- W1907569406 cites W2112599054 @default.
- W1907569406 cites W2113588666 @default.
- W1907569406 cites W2116634113 @default.
- W1907569406 cites W2116816603 @default.
- W1907569406 cites W2117792884 @default.
- W1907569406 cites W2121091193 @default.
- W1907569406 cites W2121417064 @default.
- W1907569406 cites W2125154191 @default.
- W1907569406 cites W2126525177 @default.
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- W1907569406 cites W2129924706 @default.
- W1907569406 cites W2130222411 @default.
- W1907569406 cites W2130523009 @default.
- W1907569406 cites W2131681506 @default.
- W1907569406 cites W2134087142 @default.