Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907589622> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1907589622 endingPage "2055" @default.
- W1907589622 startingPage "2052" @default.
- W1907589622 abstract "Immunoglobulin heavy chains of myeloma proteins from dogs and cata have been subjected to automated sequence analysis. When the results were compared with human heavy-chain sequences, all the dog and cat proteins could be unequivocally assigned to the V H III subgroup. This pattern contrasts with that in human proteins in which only 25% of all heavy chains sequenced belong to this subgroup. The 30 residues at the NH 2 termini of dog, cat, and human heavy chains had sequence identities near or exceeding 90%, in contrast to established interspecies sequence homologies of constant regions of about 60%. Some genes of the immunoglobulin heavy-chain variable region thus appear to have been conserved through a considerable period of evolutionary time. The analyses also showed that the presence of certain amino acids at certain positions in these heavy chains could be correlated with the species of origin. The occurrence of such “phylogenetically associated” residues is most consistent with the presence of a restricted number of genes in the heavy-chain variable region pool." @default.
- W1907589622 created "2016-06-24" @default.
- W1907589622 creator A5007832640 @default.
- W1907589622 creator A5069060812 @default.
- W1907589622 date "1972-08-01" @default.
- W1907589622 modified "2023-10-16" @default.
- W1907589622 title "Sequence Relationships among the Variable Regions of Immunoglobulin Heavy Chains from Various Mammalian Species" @default.
- W1907589622 cites W1524296956 @default.
- W1907589622 cites W1563571813 @default.
- W1907589622 cites W1965933027 @default.
- W1907589622 cites W1969118181 @default.
- W1907589622 cites W1980038436 @default.
- W1907589622 cites W1982054744 @default.
- W1907589622 cites W1983895951 @default.
- W1907589622 cites W2004060933 @default.
- W1907589622 cites W2005138172 @default.
- W1907589622 cites W2006973026 @default.
- W1907589622 cites W2013556162 @default.
- W1907589622 cites W2035297862 @default.
- W1907589622 cites W2038681434 @default.
- W1907589622 cites W2040462944 @default.
- W1907589622 cites W2050002970 @default.
- W1907589622 cites W2058126964 @default.
- W1907589622 cites W2069310769 @default.
- W1907589622 cites W2075451170 @default.
- W1907589622 cites W2092638671 @default.
- W1907589622 cites W2102664819 @default.
- W1907589622 cites W2127552260 @default.
- W1907589622 cites W2151351349 @default.
- W1907589622 doi "https://doi.org/10.1073/pnas.69.8.2052" @default.
- W1907589622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/426866" @default.
- W1907589622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4506072" @default.
- W1907589622 hasPublicationYear "1972" @default.
- W1907589622 type Work @default.
- W1907589622 sameAs 1907589622 @default.
- W1907589622 citedByCount "28" @default.
- W1907589622 crossrefType "journal-article" @default.
- W1907589622 hasAuthorship W1907589622A5007832640 @default.
- W1907589622 hasAuthorship W1907589622A5069060812 @default.
- W1907589622 hasBestOaLocation W19075896222 @default.
- W1907589622 hasConcept C104317684 @default.
- W1907589622 hasConcept C159654299 @default.
- W1907589622 hasConcept C167625842 @default.
- W1907589622 hasConcept C188758523 @default.
- W1907589622 hasConcept C199216141 @default.
- W1907589622 hasConcept C2778112365 @default.
- W1907589622 hasConcept C36394416 @default.
- W1907589622 hasConcept C515207424 @default.
- W1907589622 hasConcept C54355233 @default.
- W1907589622 hasConcept C84613547 @default.
- W1907589622 hasConcept C86803240 @default.
- W1907589622 hasConcept C96007430 @default.
- W1907589622 hasConceptScore W1907589622C104317684 @default.
- W1907589622 hasConceptScore W1907589622C159654299 @default.
- W1907589622 hasConceptScore W1907589622C167625842 @default.
- W1907589622 hasConceptScore W1907589622C188758523 @default.
- W1907589622 hasConceptScore W1907589622C199216141 @default.
- W1907589622 hasConceptScore W1907589622C2778112365 @default.
- W1907589622 hasConceptScore W1907589622C36394416 @default.
- W1907589622 hasConceptScore W1907589622C515207424 @default.
- W1907589622 hasConceptScore W1907589622C54355233 @default.
- W1907589622 hasConceptScore W1907589622C84613547 @default.
- W1907589622 hasConceptScore W1907589622C86803240 @default.
- W1907589622 hasConceptScore W1907589622C96007430 @default.
- W1907589622 hasIssue "8" @default.
- W1907589622 hasLocation W19075896221 @default.
- W1907589622 hasLocation W19075896222 @default.
- W1907589622 hasLocation W19075896223 @default.
- W1907589622 hasLocation W19075896224 @default.
- W1907589622 hasOpenAccess W1907589622 @default.
- W1907589622 hasPrimaryLocation W19075896221 @default.
- W1907589622 hasRelatedWork W1504111666 @default.
- W1907589622 hasRelatedWork W1529840361 @default.
- W1907589622 hasRelatedWork W1553994434 @default.
- W1907589622 hasRelatedWork W1907589622 @default.
- W1907589622 hasRelatedWork W1985921964 @default.
- W1907589622 hasRelatedWork W2058910307 @default.
- W1907589622 hasRelatedWork W2091394389 @default.
- W1907589622 hasRelatedWork W2803548686 @default.
- W1907589622 hasRelatedWork W314431886 @default.
- W1907589622 hasRelatedWork W3174912140 @default.
- W1907589622 hasVolume "69" @default.
- W1907589622 isParatext "false" @default.
- W1907589622 isRetracted "false" @default.
- W1907589622 magId "1907589622" @default.
- W1907589622 workType "article" @default.