FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907707905> ?p ?o ?g. }

• W1907707905 endingPage "6091" @default.
• W1907707905 startingPage "6083" @default.
• W1907707905 abstract "The infection of woodchucks with woodchuck hepatitis virus (WHV) provides an experimental model to study early immune responses during hepadnavirus infection that cannot be tested in patients. The T-cell response of experimentally WHV-infected woodchucks to WHsAg, rWHcAg, and WHcAg peptides was monitored by observing 5-bromo-2'-deoxyuridine and [2-3H]adenine incorporation. The first T-cell responses were directed against WHsAg 3 weeks after infection; these were followed by responses to rWHcAg including the immunodominant T-cell epitope of WHcAg (amino acids 97 to 110). Maximal proliferative responses were detected when the animals seroconvered to anti-WHs and anti-WHc (week 6). A decrease in the T-cell response to viral antigens coincided with clearance of viral DNA. Polyclonal rWHcAg-specific T-cell lines were established 6, 12, 18, and 24 weeks postinfection, and their responses to WHcAg peptides were assessed. Five to seven peptides including the immunodominant epitope were recognized throughout the observation period (6 months). At 12 months after infection, T-cell responses to antigens and peptides were not detected. Reactivation of T-cell responses to viral antigens and peptides occurred within 7 days after challenge of animals with WHV. These results demonstrate that a fast and vigorous T-cell response to WHsAg, rWHcAg, and amino acids 97 to 110 of the WHcAg occurs within 3 weeks after WHV infection. The peak of this response was associated with viral clearance and may be crucial for recovery from infection. One year after infection, no proliferation of T cells in response to antigens was observed; however, the WHV-specific T-cell response was reactivated after challenge of woodchucks with WHV and may be responsible for protection against WHV reinfection." @default.
• W1907707905 created "2016-06-24" @default.
• W1907707905 creator A5023717087 @default.
• W1907707905 creator A5063783789 @default.
• W1907707905 creator A5075388981 @default.
• W1907707905 creator A5082162455 @default.
• W1907707905 creator A5089789550 @default.
• W1907707905 date "1998-07-01" @default.
• W1907707905 modified "2023-10-14" @default.
• W1907707905 title "T-Cell Response to Woodchuck Hepatitis Virus (WHV) Antigens during Acute Self-Limited WHV Infection and Convalescence and after Viral Challenge" @default.
• W1907707905 cites W1498637003 @default.
• W1907707905 cites W1526380295 @default.
• W1907707905 cites W1559998622 @default.
• W1907707905 cites W1672765421 @default.
• W1907707905 cites W1751026994 @default.
• W1907707905 cites W1768221818 @default.
• W1907707905 cites W1772400723 @default.
• W1907707905 cites W1817144267 @default.
• W1907707905 cites W1845254015 @default.
• W1907707905 cites W1972942325 @default.
• W1907707905 cites W1975194312 @default.
• W1907707905 cites W1977343091 @default.
• W1907707905 cites W1984532348 @default.
• W1907707905 cites W1984533627 @default.
• W1907707905 cites W1997047331 @default.
• W1907707905 cites W2013248996 @default.
• W1907707905 cites W2018416540 @default.
• W1907707905 cites W2022337477 @default.
• W1907707905 cites W2023575698 @default.
• W1907707905 cites W2033387153 @default.
• W1907707905 cites W2036402301 @default.
• W1907707905 cites W2045299116 @default.
• W1907707905 cites W2050069496 @default.
• W1907707905 cites W2063695575 @default.
• W1907707905 cites W2083900013 @default.
• W1907707905 cites W2086847331 @default.
• W1907707905 cites W2121339743 @default.
• W1907707905 cites W2128445804 @default.
• W1907707905 cites W2144266248 @default.
• W1907707905 cites W2155688181 @default.
• W1907707905 cites W2158541247 @default.
• W1907707905 cites W2160302934 @default.
• W1907707905 cites W2173374318 @default.
• W1907707905 cites W2424601059 @default.
• W1907707905 cites W2467183266 @default.
• W1907707905 cites W4313311212 @default.
• W1907707905 doi "https://doi.org/10.1128/jvi.72.7.6083-6091.1998" @default.
• W1907707905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110414" @default.
• W1907707905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9621072" @default.
• W1907707905 hasPublicationYear "1998" @default.
• W1907707905 type Work @default.
• W1907707905 sameAs 1907707905 @default.
• W1907707905 citedByCount "60" @default.
• W1907707905 countsByYear W19077079052012 @default.
• W1907707905 countsByYear W19077079052013 @default.
• W1907707905 countsByYear W19077079052014 @default.
• W1907707905 countsByYear W19077079052015 @default.
• W1907707905 countsByYear W19077079052018 @default.
• W1907707905 countsByYear W19077079052019 @default.
• W1907707905 countsByYear W19077079052020 @default.
• W1907707905 countsByYear W19077079052022 @default.
• W1907707905 crossrefType "journal-article" @default.
• W1907707905 hasAuthorship W1907707905A5023717087 @default.
• W1907707905 hasAuthorship W1907707905A5063783789 @default.
• W1907707905 hasAuthorship W1907707905A5075388981 @default.
• W1907707905 hasAuthorship W1907707905A5082162455 @default.
• W1907707905 hasAuthorship W1907707905A5089789550 @default.
• W1907707905 hasBestOaLocation W19077079051 @default.
• W1907707905 hasConcept C147483822 @default.
• W1907707905 hasConcept C159047783 @default.
• W1907707905 hasConcept C195616568 @default.
• W1907707905 hasConcept C203014093 @default.
• W1907707905 hasConcept C2522874641 @default.
• W1907707905 hasConcept C2776090121 @default.
• W1907707905 hasConcept C2780593183 @default.
• W1907707905 hasConcept C2780617729 @default.
• W1907707905 hasConcept C2781079990 @default.
• W1907707905 hasConcept C86803240 @default.
• W1907707905 hasConcept C8891405 @default.
• W1907707905 hasConceptScore W1907707905C147483822 @default.
• W1907707905 hasConceptScore W1907707905C159047783 @default.
• W1907707905 hasConceptScore W1907707905C195616568 @default.
• W1907707905 hasConceptScore W1907707905C203014093 @default.
• W1907707905 hasConceptScore W1907707905C2522874641 @default.
• W1907707905 hasConceptScore W1907707905C2776090121 @default.
• W1907707905 hasConceptScore W1907707905C2780593183 @default.
• W1907707905 hasConceptScore W1907707905C2780617729 @default.
• W1907707905 hasConceptScore W1907707905C2781079990 @default.
• W1907707905 hasConceptScore W1907707905C86803240 @default.
• W1907707905 hasConceptScore W1907707905C8891405 @default.
• W1907707905 hasIssue "7" @default.
• W1907707905 hasLocation W19077079051 @default.
• W1907707905 hasLocation W19077079052 @default.
• W1907707905 hasLocation W19077079053 @default.
• W1907707905 hasLocation W19077079054 @default.
• W1907707905 hasOpenAccess W1907707905 @default.
• W1907707905 hasPrimaryLocation W19077079051 @default.
• W1907707905 hasRelatedWork W1494523999 @default.

• next