Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907708929> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1907708929 endingPage "5" @default.
- W1907708929 startingPage "1401" @default.
- W1907708929 abstract "The role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in the initiation and propagation of limbic motor seizures in rats was examined by the intracerebral and systemic administration of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (f) quinoxaline (NBQX), a selective antagonist of the AMPA subtype of glutamate receptor. Limbic motor seizures were evoked focally by the application of the gamma-aminobutyric acid receptor antagonist, bicuculline, into area tempestas, an epileptogenic site in the deep anterior piriform cortex. Before eliciting seizures, NBQX was applied focally into either 1) area tempestas or 2) perirhinal or posterior piriform cortex ipsilateral to the area tempestas from which seizures were evoked. In addition, pretreatment with i.p. NBQX was evaluated for anticonvulsant actions against area tempestas-evoked clonic or systemically evoked tonic seizures. In all conditions, a dose-dependent decrease in the severity of seizures was obtained with NBQX. With focal intracerebral administration, a dose of 500 pmol of NBQX consistently protected against limbic motor seizures, with partial protection achieved with 100 pmol. After i.p. administration, 2.5 and 5.0 mg/kg significantly protected the rats from both limbic motor seizures and tonic extensor seizures. No overt disturbance of spontaneous behavior was associated with the anticonvulsant doses of NBQX. Moreover, both forebrain substrates of limbic motor seizures and hindbrain substrates of tonic extensor seizures were highly susceptible to disruption by NBQX. The results indicate that AMPA subtype of glutamate receptors are crucial mediators of seizure propagation via perirhinal and piriform cortics." @default.
- W1907708929 created "2016-06-24" @default.
- W1907708929 creator A5022368369 @default.
- W1907708929 creator A5075661866 @default.
- W1907708929 creator A5083210265 @default.
- W1907708929 creator A5090743238 @default.
- W1907708929 date "1997-03-01" @default.
- W1907708929 modified "2023-10-16" @default.
- W1907708929 title "A crucial role of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures." @default.
- W1907708929 cites W1963498769 @default.
- W1907708929 cites W1978376339 @default.
- W1907708929 cites W1994421160 @default.
- W1907708929 cites W2021251623 @default.
- W1907708929 cites W2023626807 @default.
- W1907708929 cites W2042870660 @default.
- W1907708929 cites W2051875864 @default.
- W1907708929 cites W2052249757 @default.
- W1907708929 cites W2057537207 @default.
- W1907708929 cites W2093462886 @default.
- W1907708929 cites W2095358033 @default.
- W1907708929 cites W2122597724 @default.
- W1907708929 cites W2167825748 @default.
- W1907708929 cites W2410460610 @default.
- W1907708929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9067329" @default.
- W1907708929 hasPublicationYear "1997" @default.
- W1907708929 type Work @default.
- W1907708929 sameAs 1907708929 @default.
- W1907708929 citedByCount "15" @default.
- W1907708929 countsByYear W19077089292013 @default.
- W1907708929 countsByYear W19077089292014 @default.
- W1907708929 countsByYear W19077089292015 @default.
- W1907708929 countsByYear W19077089292016 @default.
- W1907708929 countsByYear W19077089292017 @default.
- W1907708929 countsByYear W19077089292019 @default.
- W1907708929 countsByYear W19077089292021 @default.
- W1907708929 crossrefType "journal-article" @default.
- W1907708929 hasAuthorship W1907708929A5022368369 @default.
- W1907708929 hasAuthorship W1907708929A5075661866 @default.
- W1907708929 hasAuthorship W1907708929A5083210265 @default.
- W1907708929 hasAuthorship W1907708929A5090743238 @default.
- W1907708929 hasConcept C126322002 @default.
- W1907708929 hasConcept C15744967 @default.
- W1907708929 hasConcept C160268369 @default.
- W1907708929 hasConcept C169760540 @default.
- W1907708929 hasConcept C170493617 @default.
- W1907708929 hasConcept C185592680 @default.
- W1907708929 hasConcept C2776885963 @default.
- W1907708929 hasConcept C2780076171 @default.
- W1907708929 hasConcept C2780382662 @default.
- W1907708929 hasConcept C2780763569 @default.
- W1907708929 hasConcept C2781161787 @default.
- W1907708929 hasConcept C42219234 @default.
- W1907708929 hasConcept C61174792 @default.
- W1907708929 hasConcept C71924100 @default.
- W1907708929 hasConcept C98274493 @default.
- W1907708929 hasConceptScore W1907708929C126322002 @default.
- W1907708929 hasConceptScore W1907708929C15744967 @default.
- W1907708929 hasConceptScore W1907708929C160268369 @default.
- W1907708929 hasConceptScore W1907708929C169760540 @default.
- W1907708929 hasConceptScore W1907708929C170493617 @default.
- W1907708929 hasConceptScore W1907708929C185592680 @default.
- W1907708929 hasConceptScore W1907708929C2776885963 @default.
- W1907708929 hasConceptScore W1907708929C2780076171 @default.
- W1907708929 hasConceptScore W1907708929C2780382662 @default.
- W1907708929 hasConceptScore W1907708929C2780763569 @default.
- W1907708929 hasConceptScore W1907708929C2781161787 @default.
- W1907708929 hasConceptScore W1907708929C42219234 @default.
- W1907708929 hasConceptScore W1907708929C61174792 @default.
- W1907708929 hasConceptScore W1907708929C71924100 @default.
- W1907708929 hasConceptScore W1907708929C98274493 @default.
- W1907708929 hasIssue "3" @default.
- W1907708929 hasLocation W19077089291 @default.
- W1907708929 hasOpenAccess W1907708929 @default.
- W1907708929 hasPrimaryLocation W19077089291 @default.
- W1907708929 hasRelatedWork W1503935526 @default.
- W1907708929 hasRelatedWork W1907708929 @default.
- W1907708929 hasRelatedWork W1999197073 @default.
- W1907708929 hasRelatedWork W2002627897 @default.
- W1907708929 hasRelatedWork W2007023757 @default.
- W1907708929 hasRelatedWork W2012548065 @default.
- W1907708929 hasRelatedWork W2055340029 @default.
- W1907708929 hasRelatedWork W2089222041 @default.
- W1907708929 hasRelatedWork W2133048825 @default.
- W1907708929 hasRelatedWork W2290799143 @default.
- W1907708929 hasVolume "280" @default.
- W1907708929 isParatext "false" @default.
- W1907708929 isRetracted "false" @default.
- W1907708929 magId "1907708929" @default.
- W1907708929 workType "article" @default.