Matches in SemOpenAlex for { <https://semopenalex.org/work/W190773950> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W190773950 abstract "Some peripheral tissues, including hepatocytes and aortic smooth muscle, possess vasopressin-responsive receptors of the V1-type. Activation of these receptors causes phosphodiesterase-catalyzed breakdown of phosphatidylinositol 4,5-bisphosppate (Ptdlns4,5P2) and leads to a rise in cytosol [(C{a^{{2^ + }}})]. It has previously been assumed that these V1-receptors are mainly responsive to changes in the concentration of circulating argininevasopressin (AVP). However, we have now identified a vasopressin-like neuropeptide (VLP) in the major noradrenergic neurones of sympathetic ganglia and in nerve fibers within sympathetically innervated tissues. It seems possible that VLP will prove to be a co-transmitter that is released with noradrenaline at sympathetic nerve terminals and varicosities, in which case VLP, rather than AVP, may be the predominant activator of V1-receptors in vivo. In addition, AVP produces a striking stimulation of Ptdlns4,5P2 breakdown in isolated superior cervical sympathetic ganglia: this response is mediated by V1-receptors and it persists when ganglia are stimulated in a medium of low Ca2+ concentration or in the presence of indomethacin. A smaller stimulation of inositollipid breakdown occurs in ganglia depolarized by high [K+) (in the presence of 10 uM atropine): this response requires extracellular Ca2+ and is insensitive to V1-receptor blockade." @default.
- W190773950 created "2016-06-24" @default.
- W190773950 creator A5003433298 @default.
- W190773950 creator A5003472896 @default.
- W190773950 creator A5003671961 @default.
- W190773950 creator A5030701256 @default.
- W190773950 creator A5030998429 @default.
- W190773950 creator A5034686830 @default.
- W190773950 creator A5059594323 @default.
- W190773950 creator A5066869479 @default.
- W190773950 creator A5087353572 @default.
- W190773950 date "1985-01-01" @default.
- W190773950 modified "2023-09-26" @default.
- W190773950 title "Inositol Lipid Breakdown in Receptor-Mediated Responses of Sympathetic Ganglia and Sympathetically Innervated Tissues" @default.
- W190773950 cites W1678105179 @default.
- W190773950 cites W1772576610 @default.
- W190773950 cites W1802980406 @default.
- W190773950 cites W1889236699 @default.
- W190773950 cites W1966925516 @default.
- W190773950 cites W1974304383 @default.
- W190773950 cites W1978151819 @default.
- W190773950 cites W1978237239 @default.
- W190773950 cites W1992518833 @default.
- W190773950 cites W1996996770 @default.
- W190773950 cites W2002178679 @default.
- W190773950 cites W2007298451 @default.
- W190773950 cites W2008245136 @default.
- W190773950 cites W2009439652 @default.
- W190773950 cites W2023938578 @default.
- W190773950 cites W2025881724 @default.
- W190773950 cites W2052699536 @default.
- W190773950 cites W2057313983 @default.
- W190773950 cites W2057750894 @default.
- W190773950 cites W2063854795 @default.
- W190773950 cites W2072099683 @default.
- W190773950 cites W2078198763 @default.
- W190773950 cites W2201257485 @default.
- W190773950 cites W2340117956 @default.
- W190773950 doi "https://doi.org/10.1007/978-1-4612-5184-2_15" @default.
- W190773950 hasPublicationYear "1985" @default.
- W190773950 type Work @default.
- W190773950 sameAs 190773950 @default.
- W190773950 citedByCount "1" @default.
- W190773950 crossrefType "book-chapter" @default.
- W190773950 hasAuthorship W190773950A5003433298 @default.
- W190773950 hasAuthorship W190773950A5003472896 @default.
- W190773950 hasAuthorship W190773950A5003671961 @default.
- W190773950 hasAuthorship W190773950A5030701256 @default.
- W190773950 hasAuthorship W190773950A5030998429 @default.
- W190773950 hasAuthorship W190773950A5034686830 @default.
- W190773950 hasAuthorship W190773950A5059594323 @default.
- W190773950 hasAuthorship W190773950A5066869479 @default.
- W190773950 hasAuthorship W190773950A5087353572 @default.
- W190773950 hasConcept C126322002 @default.
- W190773950 hasConcept C134018914 @default.
- W190773950 hasConcept C170493617 @default.
- W190773950 hasConcept C185592680 @default.
- W190773950 hasConcept C24998067 @default.
- W190773950 hasConcept C2776370428 @default.
- W190773950 hasConcept C2776885963 @default.
- W190773950 hasConcept C71924100 @default.
- W190773950 hasConcept C86803240 @default.
- W190773950 hasConcept C90474776 @default.
- W190773950 hasConceptScore W190773950C126322002 @default.
- W190773950 hasConceptScore W190773950C134018914 @default.
- W190773950 hasConceptScore W190773950C170493617 @default.
- W190773950 hasConceptScore W190773950C185592680 @default.
- W190773950 hasConceptScore W190773950C24998067 @default.
- W190773950 hasConceptScore W190773950C2776370428 @default.
- W190773950 hasConceptScore W190773950C2776885963 @default.
- W190773950 hasConceptScore W190773950C71924100 @default.
- W190773950 hasConceptScore W190773950C86803240 @default.
- W190773950 hasConceptScore W190773950C90474776 @default.
- W190773950 hasLocation W1907739501 @default.
- W190773950 hasOpenAccess W190773950 @default.
- W190773950 hasPrimaryLocation W1907739501 @default.
- W190773950 hasRelatedWork W1987492115 @default.
- W190773950 hasRelatedWork W1990541407 @default.
- W190773950 hasRelatedWork W2007298451 @default.
- W190773950 hasRelatedWork W2017874551 @default.
- W190773950 hasRelatedWork W2048145699 @default.
- W190773950 hasRelatedWork W2091217285 @default.
- W190773950 hasRelatedWork W2121212465 @default.
- W190773950 hasRelatedWork W2123706010 @default.
- W190773950 hasRelatedWork W2254731252 @default.
- W190773950 hasRelatedWork W227411212 @default.
- W190773950 hasRelatedWork W2292983361 @default.
- W190773950 hasRelatedWork W2404580168 @default.
- W190773950 hasRelatedWork W2411546588 @default.
- W190773950 hasRelatedWork W2414214568 @default.
- W190773950 hasRelatedWork W2416962651 @default.
- W190773950 hasRelatedWork W2466175975 @default.
- W190773950 hasRelatedWork W2500187724 @default.
- W190773950 hasRelatedWork W3100692890 @default.
- W190773950 hasRelatedWork W2027753296 @default.
- W190773950 hasRelatedWork W2414398028 @default.
- W190773950 isParatext "false" @default.
- W190773950 isRetracted "false" @default.
- W190773950 magId "190773950" @default.
- W190773950 workType "book-chapter" @default.