Matches in SemOpenAlex for { <https://semopenalex.org/work/W19078023> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W19078023 endingPage "16" @default.
- W19078023 startingPage "9" @default.
- W19078023 abstract "Objective Calcium Glucarate (Cag), Ca salt of D-glucaric acid is a naturally occurring non-toxic compound present in fruits, vegetables and seeds of some plants, and suppress tumor growth in different models. Due to lack of knowledge about its mode of action its uses are limited in cancer chemotherapy thus the objective of the study was to study the mechanism of action of Cag on mouse skin tumorigenesis. Methods We have estimated effect of Cag on DMBA induced mouse skin tumor development following complete carcinogenesis protocol. We measured, epidermal transglutaminase activity (TG), a marker of cell differentiation after DMBA and/or Cag treatment and [3H] thymidine incorporation into DNA as a marker for cell proliferation. Results Topical application of Cag suppressed the DMBA induced mouse skin tumor development. Topical application of Cag significantly modifies the critical events of proliferation and differentiation TG activity was found to be reduced after DMBA treatment. Reduction of the TG activity was dependent on the dose of DMBA and duration of DMBA exposure. Topical application of Cag significantly alleviated DMBA induced inhibition of TG. DMBA also caused stimulation of DNA synthesis in epidermis, which was inhibited by Cag. Conclusion Cag inhibits DMBA induced mouse skin tumor development. Since stimulation of DNA synthesis reflects proliferation and induction of TG represents differentiation, the antitumorigenic effect of Cag is considered to be possibly due to stimulation of differentiation and suppression of proliferation." @default.
- W19078023 created "2016-06-24" @default.
- W19078023 creator A5057939323 @default.
- W19078023 date "2003-01-01" @default.
- W19078023 modified "2023-09-24" @default.
- W19078023 title "Calcium Glucarate Prevents Tumor Formation in Mouse Skin" @default.
- W19078023 hasPublicationYear "2003" @default.
- W19078023 type Work @default.
- W19078023 sameAs 19078023 @default.
- W19078023 citedByCount "0" @default.
- W19078023 crossrefType "journal-article" @default.
- W19078023 hasAuthorship W19078023A5057939323 @default.
- W19078023 hasConcept C104317684 @default.
- W19078023 hasConcept C105702510 @default.
- W19078023 hasConcept C134018914 @default.
- W19078023 hasConcept C185592680 @default.
- W19078023 hasConcept C24998067 @default.
- W19078023 hasConcept C2776458125 @default.
- W19078023 hasConcept C2778287671 @default.
- W19078023 hasConcept C2778938436 @default.
- W19078023 hasConcept C502942594 @default.
- W19078023 hasConcept C552990157 @default.
- W19078023 hasConcept C55493867 @default.
- W19078023 hasConcept C555283112 @default.
- W19078023 hasConcept C62112901 @default.
- W19078023 hasConcept C64241487 @default.
- W19078023 hasConcept C86803240 @default.
- W19078023 hasConcept C98274493 @default.
- W19078023 hasConceptScore W19078023C104317684 @default.
- W19078023 hasConceptScore W19078023C105702510 @default.
- W19078023 hasConceptScore W19078023C134018914 @default.
- W19078023 hasConceptScore W19078023C185592680 @default.
- W19078023 hasConceptScore W19078023C24998067 @default.
- W19078023 hasConceptScore W19078023C2776458125 @default.
- W19078023 hasConceptScore W19078023C2778287671 @default.
- W19078023 hasConceptScore W19078023C2778938436 @default.
- W19078023 hasConceptScore W19078023C502942594 @default.
- W19078023 hasConceptScore W19078023C552990157 @default.
- W19078023 hasConceptScore W19078023C55493867 @default.
- W19078023 hasConceptScore W19078023C555283112 @default.
- W19078023 hasConceptScore W19078023C62112901 @default.
- W19078023 hasConceptScore W19078023C64241487 @default.
- W19078023 hasConceptScore W19078023C86803240 @default.
- W19078023 hasConceptScore W19078023C98274493 @default.
- W19078023 hasIssue "1" @default.
- W19078023 hasLocation W190780231 @default.
- W19078023 hasOpenAccess W19078023 @default.
- W19078023 hasPrimaryLocation W190780231 @default.
- W19078023 hasRelatedWork W1537509109 @default.
- W19078023 hasRelatedWork W1553793186 @default.
- W19078023 hasRelatedWork W1905751505 @default.
- W19078023 hasRelatedWork W2017027387 @default.
- W19078023 hasRelatedWork W2018472319 @default.
- W19078023 hasRelatedWork W2037172610 @default.
- W19078023 hasRelatedWork W2047479359 @default.
- W19078023 hasRelatedWork W2078958553 @default.
- W19078023 hasRelatedWork W2082899876 @default.
- W19078023 hasRelatedWork W2087161734 @default.
- W19078023 hasRelatedWork W2126114727 @default.
- W19078023 hasRelatedWork W2135334331 @default.
- W19078023 hasRelatedWork W2149435549 @default.
- W19078023 hasRelatedWork W2155163244 @default.
- W19078023 hasRelatedWork W2157859369 @default.
- W19078023 hasRelatedWork W2330229747 @default.
- W19078023 hasRelatedWork W2333893563 @default.
- W19078023 hasRelatedWork W2413382635 @default.
- W19078023 hasRelatedWork W3082024093 @default.
- W19078023 hasRelatedWork W3092528701 @default.
- W19078023 hasVolume "16" @default.
- W19078023 isParatext "false" @default.
- W19078023 isRetracted "false" @default.
- W19078023 magId "19078023" @default.
- W19078023 workType "article" @default.