FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907900083> ?p ?o ?g. }

• W1907900083 abstract "Recent studies have been explained the role of lipoxygenases (LOX) in the origin of cancer. Among the lipoxygenases, the 5-LOX, 12-LOX and 15-LOX are more important in the cause of neoplastic disorders. In the present investigation, a new series of anticancer agents with 1,3,4-thiadiazole and phthalimide substructures were synthesized and their in vitro cytotoxicity was evaluated by MTT assay. Moreover, enzyme inhibitory potency was also assessed by enzymatic protocol towards 15-LOX-1. Molecular docking was performed to explore in silico binding mode of the target compounds.Tested compounds showed a better cytotoxic activity against HT29 cell line (colorectal cancer) in comparison with other cell lines (PC3: prostate carcinoma; SKNMC: neuroblastoma). Unfortunately, all of the tested derivatives rendered lower inhibitory potency than quercetin towards 15-LOX-1. Four hydrogen bonds were detected in docking studies for compound 4d as the most potent derivative in enzymatic assay.The biological results of reported compounds in this research were not so satisfactory. But, further structural modifications are necessary to improve the bioactivity of these derivatives." @default.
• W1907900083 created "2016-06-24" @default.
• W1907900083 creator A5015147973 @default.
• W1907900083 creator A5028752327 @default.
• W1907900083 creator A5036195935 @default.
• W1907900083 creator A5039058390 @default.
• W1907900083 creator A5044682595 @default.
• W1907900083 creator A5069351562 @default.
• W1907900083 date "2015-07-22" @default.
• W1907900083 modified "2023-10-08" @default.
• W1907900083 title "Phthalimide analogs as probable 15-lipoxygenase-1 inhibitors: synthesis, biological evaluation and docking studies" @default.
• W1907900083 cites W1555428651 @default.
• W1907900083 cites W1601657151 @default.
• W1907900083 cites W1758717111 @default.
• W1907900083 cites W1972251315 @default.
• W1907900083 cites W1979555734 @default.
• W1907900083 cites W2002219327 @default.
• W1907900083 cites W2006361174 @default.
• W1907900083 cites W2017104482 @default.
• W1907900083 cites W2035902905 @default.
• W1907900083 cites W2038657639 @default.
• W1907900083 cites W2043374469 @default.
• W1907900083 cites W2048148626 @default.
• W1907900083 cites W2067546903 @default.
• W1907900083 cites W2076677873 @default.
• W1907900083 cites W2081577661 @default.
• W1907900083 cites W2088099558 @default.
• W1907900083 cites W2090421465 @default.
• W1907900083 cites W2092745115 @default.
• W1907900083 cites W2120976484 @default.
• W1907900083 cites W2126176221 @default.
• W1907900083 cites W2149637115 @default.
• W1907900083 cites W2154754488 @default.
• W1907900083 cites W2163161387 @default.
• W1907900083 cites W2163177774 @default.
• W1907900083 cites W2164736711 @default.
• W1907900083 cites W2284643145 @default.
• W1907900083 cites W2417117689 @default.
• W1907900083 cites W2784297274 @default.
• W1907900083 cites W2992729463 @default.
• W1907900083 cites W1621219820 @default.
• W1907900083 cites W2135874105 @default.
• W1907900083 doi "https://doi.org/10.1186/s40199-015-0118-5" @default.
• W1907900083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4509565" @default.
• W1907900083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26197788" @default.
• W1907900083 hasPublicationYear "2015" @default.
• W1907900083 type Work @default.
• W1907900083 sameAs 1907900083 @default.
• W1907900083 citedByCount "4" @default.
• W1907900083 countsByYear W19079000832016 @default.
• W1907900083 countsByYear W19079000832018 @default.
• W1907900083 countsByYear W19079000832020 @default.
• W1907900083 countsByYear W19079000832023 @default.
• W1907900083 crossrefType "journal-article" @default.
• W1907900083 hasAuthorship W1907900083A5015147973 @default.
• W1907900083 hasAuthorship W1907900083A5028752327 @default.
• W1907900083 hasAuthorship W1907900083A5036195935 @default.
• W1907900083 hasAuthorship W1907900083A5039058390 @default.
• W1907900083 hasAuthorship W1907900083A5044682595 @default.
• W1907900083 hasAuthorship W1907900083A5069351562 @default.
• W1907900083 hasBestOaLocation W19079000831 @default.
• W1907900083 hasConcept C104317684 @default.
• W1907900083 hasConcept C109316439 @default.
• W1907900083 hasConcept C159110408 @default.
• W1907900083 hasConcept C181199279 @default.
• W1907900083 hasConcept C185592680 @default.
• W1907900083 hasConcept C202751555 @default.
• W1907900083 hasConcept C2775905019 @default.
• W1907900083 hasConcept C2776889390 @default.
• W1907900083 hasConcept C2778522978 @default.
• W1907900083 hasConcept C2780783641 @default.
• W1907900083 hasConcept C2780857362 @default.
• W1907900083 hasConcept C41685203 @default.
• W1907900083 hasConcept C55493867 @default.
• W1907900083 hasConcept C57992300 @default.
• W1907900083 hasConcept C71240020 @default.
• W1907900083 hasConcept C71924100 @default.
• W1907900083 hasConcept C86803240 @default.
• W1907900083 hasConcept C98274493 @default.
• W1907900083 hasConceptScore W1907900083C104317684 @default.
• W1907900083 hasConceptScore W1907900083C109316439 @default.
• W1907900083 hasConceptScore W1907900083C159110408 @default.
• W1907900083 hasConceptScore W1907900083C181199279 @default.
• W1907900083 hasConceptScore W1907900083C185592680 @default.
• W1907900083 hasConceptScore W1907900083C202751555 @default.
• W1907900083 hasConceptScore W1907900083C2775905019 @default.
• W1907900083 hasConceptScore W1907900083C2776889390 @default.
• W1907900083 hasConceptScore W1907900083C2778522978 @default.
• W1907900083 hasConceptScore W1907900083C2780783641 @default.
• W1907900083 hasConceptScore W1907900083C2780857362 @default.
• W1907900083 hasConceptScore W1907900083C41685203 @default.
• W1907900083 hasConceptScore W1907900083C55493867 @default.
• W1907900083 hasConceptScore W1907900083C57992300 @default.
• W1907900083 hasConceptScore W1907900083C71240020 @default.
• W1907900083 hasConceptScore W1907900083C71924100 @default.
• W1907900083 hasConceptScore W1907900083C86803240 @default.
• W1907900083 hasConceptScore W1907900083C98274493 @default.
• W1907900083 hasLocation W19079000831 @default.
• W1907900083 hasLocation W19079000832 @default.
• W1907900083 hasLocation W19079000833 @default.

• next