FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1907939438> ?p ?o ?g. }

• W1907939438 endingPage "23" @default.
• W1907939438 startingPage "717" @default.
• W1907939438 abstract "Controversy exists over levels of DNA integrity in the sperm of fertile and infertile men. In addition, the effect of leukocytospermia on sperm DNA in these 2 groups is unclear. We decided to address these questions by collecting semen samples from men known or presumed to be fertile and men from infertile couples. Samples were analyzed and assessed for sperm concentration, motility, and morphology. Samples failing to meet World Health Organization (WHO) standards in one or more of these parameters were judged abnormal. Samples were then arbitrarily assigned normalized scores in each of the above parameters, and scores were summed to give a normalized value for overall sperm quality. DNA abnormality was determined by an in situ DNA denaturation test with acridine orange and expressed as a percentage of cells with abnormal DNA integrity (ADI). Assessment of 187 samples revealed a moderate inverse correlation between ADI and sperm quality (r =.58), although a large degree of ADI dispersion was observed in abnormal semen samples. The average ADI for normal and abnormal semen samples was 18% +/- 2.8% and 36% +/- 5.8%, respectively, with the threshold of 95% probability set at 30%. When sorted for leukocytospermia, the difference in ADI between normal and abnormal semen groups without leukocytospermia was much smaller (17% +/- 2.2% and 22% +/- 4.6%; P =.023). Leukocytospermia had no significant effect on ADI in the normal semen group (P = .46); however, ADI was more than double the ADI in the abnormal semen group (18% +/- 2.4% and 50% +/- 11%; P < .001). The results of our analysis show that at least 3 factors affect net DNA integrity in leukocytospermic samples that fail to meet WHO standards: 1) primary DNA damage, which is moderately inverse to sperm quality, in particular to sperm concentration; 2) effect of leukocytes increasing primary or provoking potential DNA damage in a cascade-like manner, particularly in sperm with poor morphology and motility; and 3) a decreasing proportion of cells with damaged DNA in semen with the worst quality." @default.
• W1907939438 created "2016-06-24" @default.
• W1907939438 creator A5024286455 @default.
• W1907939438 creator A5036277461 @default.
• W1907939438 creator A5068208266 @default.
• W1907939438 creator A5079919637 @default.
• W1907939438 date "2002-08-20" @default.
• W1907939438 modified "2023-10-16" @default.
• W1907939438 title "Effect of leukocytospermia on sperm DNA integrity: a negative effect in abnormal semen samples." @default.
• W1907939438 cites W129593572 @default.
• W1907939438 cites W1506187431 @default.
• W1907939438 cites W1738032870 @default.
• W1907939438 cites W1951531523 @default.
• W1907939438 cites W1975350721 @default.
• W1907939438 cites W1983884639 @default.
• W1907939438 cites W1994291765 @default.
• W1907939438 cites W2001507834 @default.
• W1907939438 cites W2036183167 @default.
• W1907939438 cites W2047270772 @default.
• W1907939438 cites W2052337911 @default.
• W1907939438 cites W2053192002 @default.
• W1907939438 cites W2059783500 @default.
• W1907939438 cites W2076065287 @default.
• W1907939438 cites W2089889551 @default.
• W1907939438 cites W2104202525 @default.
• W1907939438 cites W2109269254 @default.
• W1907939438 cites W2118944887 @default.
• W1907939438 cites W2130558040 @default.
• W1907939438 cites W2144975929 @default.
• W1907939438 cites W2147148630 @default.
• W1907939438 cites W2154792019 @default.
• W1907939438 cites W2162767305 @default.
• W1907939438 cites W2170794875 @default.
• W1907939438 cites W2272838734 @default.
• W1907939438 cites W2275274443 @default.
• W1907939438 cites W2346419360 @default.
• W1907939438 cites W2417383855 @default.
• W1907939438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12185107" @default.
• W1907939438 hasPublicationYear "2002" @default.
• W1907939438 type Work @default.
• W1907939438 sameAs 1907939438 @default.
• W1907939438 citedByCount "29" @default.
• W1907939438 countsByYear W19079394382012 @default.
• W1907939438 countsByYear W19079394382013 @default.
• W1907939438 countsByYear W19079394382014 @default.
• W1907939438 countsByYear W19079394382015 @default.
• W1907939438 countsByYear W19079394382016 @default.
• W1907939438 countsByYear W19079394382017 @default.
• W1907939438 countsByYear W19079394382018 @default.
• W1907939438 countsByYear W19079394382020 @default.
• W1907939438 countsByYear W19079394382022 @default.
• W1907939438 crossrefType "journal-article" @default.
• W1907939438 hasAuthorship W1907939438A5024286455 @default.
• W1907939438 hasAuthorship W1907939438A5036277461 @default.
• W1907939438 hasAuthorship W1907939438A5068208266 @default.
• W1907939438 hasAuthorship W1907939438A5079919637 @default.
• W1907939438 hasConcept C16685009 @default.
• W1907939438 hasConcept C2777338322 @default.
• W1907939438 hasConcept C2777589648 @default.
• W1907939438 hasConcept C2777632594 @default.
• W1907939438 hasConcept C2777688143 @default.
• W1907939438 hasConcept C2778080409 @default.
• W1907939438 hasConcept C2778093475 @default.
• W1907939438 hasConcept C2779102032 @default.
• W1907939438 hasConcept C2779234561 @default.
• W1907939438 hasConcept C2781087480 @default.
• W1907939438 hasConcept C54355233 @default.
• W1907939438 hasConcept C71924100 @default.
• W1907939438 hasConcept C74864618 @default.
• W1907939438 hasConcept C86803240 @default.
• W1907939438 hasConceptScore W1907939438C16685009 @default.
• W1907939438 hasConceptScore W1907939438C2777338322 @default.
• W1907939438 hasConceptScore W1907939438C2777589648 @default.
• W1907939438 hasConceptScore W1907939438C2777632594 @default.
• W1907939438 hasConceptScore W1907939438C2777688143 @default.
• W1907939438 hasConceptScore W1907939438C2778080409 @default.
• W1907939438 hasConceptScore W1907939438C2778093475 @default.
• W1907939438 hasConceptScore W1907939438C2779102032 @default.
• W1907939438 hasConceptScore W1907939438C2779234561 @default.
• W1907939438 hasConceptScore W1907939438C2781087480 @default.
• W1907939438 hasConceptScore W1907939438C54355233 @default.
• W1907939438 hasConceptScore W1907939438C71924100 @default.
• W1907939438 hasConceptScore W1907939438C74864618 @default.
• W1907939438 hasConceptScore W1907939438C86803240 @default.
• W1907939438 hasIssue "5" @default.
• W1907939438 hasLocation W19079394381 @default.
• W1907939438 hasOpenAccess W1907939438 @default.
• W1907939438 hasPrimaryLocation W19079394381 @default.
• W1907939438 hasRelatedWork W126364770 @default.
• W1907939438 hasRelatedWork W1907939438 @default.
• W1907939438 hasRelatedWork W1973007694 @default.
• W1907939438 hasRelatedWork W2033610051 @default.
• W1907939438 hasRelatedWork W2112570479 @default.
• W1907939438 hasRelatedWork W2122663950 @default.
• W1907939438 hasRelatedWork W2376515096 @default.
• W1907939438 hasRelatedWork W2810831063 @default.
• W1907939438 hasRelatedWork W3075680427 @default.
• W1907939438 hasRelatedWork W3193094673 @default.

• next