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- W1908082172 abstract "Exercise has positive effects on central nervous system, especially when there is a context of disorder.1 Considering the prevalence of Alzheimer's disease and lack of a decisive treatment, this study aimed to evaluate the effect of exercise on learning and memory in rats after intracerebroventricular injection of streptozotocin (ICV-STZ), a well defined model for Alzheimer's disease .2Experimental groups consisted of sham-rest, sham-exercise, lesion-rest and lesion-exercise groups. Rats in lesion group received ICV-STZ. In the exercise group, rats were made to run on a treadmill (20 m/min, 0-degree inclination, 50 min/day, 4 weeks). Morris water maze test was used to evaluate spatial learning and memory.The results showed that spatial learning and memory indices were significantly impaired in the rats with ICV-STZ (Figure 1). However, exercise prevented impairments as there was a significant difference between lesion-exercise and lesion-rest groups.Figure 1Effects of exercise and ICV-STZ on the escape latencies (A) and the path length (B) at different block to reach the platform (lower numbers indicate better performance); and performance during the probe trials as measured by mean percentage (%) of time ...The findings of this study suggested that similar to Alzheimer's disease, ICV-STZ severely impairs cognitive process, but exercise prevents this damage. Therefore, exercise probably is helpful in prevention and alleviation of cognitive disorders in Alzheimer's disease." @default.
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- W1908082172 date "2011-10-01" @default.
- W1908082172 modified "2023-09-23" @default.
- W1908082172 title "Treadmill running improves spatial learning and memory in the rats with intracerebroventricular injection of streptozotocin." @default.
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